BDBM50208220 1-(5-chlorobenzo[b]thiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl(phenethyl)phosphinic acid::CHEMBL373820

SMILES: OP(=O)(CCc1ccccc1)C(C(=O)Nc1ccc2ccccc2c1)c1csc2ccc(Cl)cc12

InChI Key: InChIKey=PRNSPHBMPVHQDP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50208220   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM50208220 (1-(5-chlorobenzo[b]thiophen-3-yl)-2-(naphthalen-2-...) Show SMILES OP(=O)(CCc1ccccc1)C(C(=O)Nc1ccc2ccccc2c1)c1csc2ccc(Cl)cc12 Show InChI InChI=1S/C28H23ClNO3PS/c29-22-11-13-26-24(17-22)25(18-35-26)27(34(32,33)15-14-19-6-2-1-3-7-19)28(31)30-23-12-10-20-8-4-5-9-21(20)16-23/h1-13,16-18,27H,14-15H2,(H,30,31)(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of human skin chymase				J Med Chem 50: 1727-30 (2007) Article DOI: 10.1021/jm0700619 BindingDB Entry DOI: 10.7270/Q26W99RF
					More data for this Ligand-Target Pair