BDBM50208221 1-(5-chlorobenzo[b]thiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl(methyl)phosphinic acid::CHEMBL373846

SMILES: CP(O)(=O)C(C(=O)Nc1ccc2ccccc2c1)c1csc2ccc(Cl)cc12

InChI Key: InChIKey=GZXIXQPDOFCECC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50208221   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM50208221 (1-(5-chlorobenzo[b]thiophen-3-yl)-2-(naphthalen-2-...) Show SMILES CP(O)(=O)C(C(=O)Nc1ccc2ccccc2c1)c1csc2ccc(Cl)cc12 Show InChI InChI=1S/C21H17ClNO3PS/c1-27(25,26)20(18-12-28-19-9-7-15(22)11-17(18)19)21(24)23-16-8-6-13-4-2-3-5-14(13)10-16/h2-12,20H,1H3,(H,23,24)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of human skin chymase				J Med Chem 50: 1727-30 (2007) Article DOI: 10.1021/jm0700619 BindingDB Entry DOI: 10.7270/Q26W99RF
					More data for this Ligand-Target Pair