BDBM50208229 (E)-2-(3,4-difluorostyrylamino)-1-(5-chloro-1-methyl-1H-indol-3-yl)-2-oxoethyl(methyl)phosphinic acid::CHEMBL376054

SMILES: Cn1cc(C(C(=O)NC=Cc2ccc(F)c(F)c2)P(C)(O)=O)c2cc(Cl)ccc12

InChI Key: InChIKey=YSTBMZYRZAUFPV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50208229   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM50208229 ((E)-2-(3,4-difluorostyrylamino)-1-(5-chloro-1-meth...) Show SMILES Cn1cc(C(C(=O)NC=Cc2ccc(F)c(F)c2)P(C)(O)=O)c2cc(Cl)ccc12 |w:9.9| Show InChI InChI=1S/C20H18ClF2N2O3P/c1-25-11-15(14-10-13(21)4-6-18(14)25)19(29(2,27)28)20(26)24-8-7-12-3-5-16(22)17(23)9-12/h3-11,19H,1-2H3,(H,24,26)(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of human skin chymase				J Med Chem 50: 1727-30 (2007) Article DOI: 10.1021/jm0700619 BindingDB Entry DOI: 10.7270/Q26W99RF
					More data for this Ligand-Target Pair