BDBM50208230 2-(3,4-difluorophenethylamino)-1-(5-chlorobenzo[b]thiophen-3-yl)-2-oxoethyl(methyl)phosphinic acid::CHEMBL373622

SMILES: CP(O)(=O)C(C(=O)NCCc1ccc(F)c(F)c1)c1csc2ccc(Cl)cc12

InChI Key: InChIKey=YWRCQCSBIGFKMK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50208230   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM50208230 (2-(3,4-difluorophenethylamino)-1-(5-chlorobenzo[b]...) Show SMILES CP(O)(=O)C(C(=O)NCCc1ccc(F)c(F)c1)c1csc2ccc(Cl)cc12 Show InChI InChI=1S/C19H17ClF2NO3PS/c1-27(25,26)18(14-10-28-17-5-3-12(20)9-13(14)17)19(24)23-7-6-11-2-4-15(21)16(22)8-11/h2-5,8-10,18H,6-7H2,1H3,(H,23,24)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of human skin chymase				J Med Chem 50: 1727-30 (2007) Article DOI: 10.1021/jm0700619 BindingDB Entry DOI: 10.7270/Q26W99RF
					More data for this Ligand-Target Pair