BDBM50208235 (E)-2-(3,4-difluorostyrylamino)-1-(5-chlorobenzo[b]thiophen-3-yl)-2-oxoethyl(ethyl)phosphinic acid::CHEMBL223183

SMILES: CCP(O)(=O)C(C(=O)NC=Cc1ccc(F)c(F)c1)c1csc2ccc(Cl)cc12

InChI Key: InChIKey=OQZFHRRYYSVINB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50208235   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM50208235 ((E)-2-(3,4-difluorostyrylamino)-1-(5-chlorobenzo[b...) Show SMILES CCP(O)(=O)C(C(=O)NC=Cc1ccc(F)c(F)c1)c1csc2ccc(Cl)cc12 |w:10.10| Show InChI InChI=1S/C20H17ClF2NO3PS/c1-2-28(26,27)19(15-11-29-18-6-4-13(21)10-14(15)18)20(25)24-8-7-12-3-5-16(22)17(23)9-12/h3-11,19H,2H2,1H3,(H,24,25)(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of human skin chymase				J Med Chem 50: 1727-30 (2007) Article DOI: 10.1021/jm0700619 BindingDB Entry DOI: 10.7270/Q26W99RF
					More data for this Ligand-Target Pair