BDBM50208239 (E)-2-(4-fluorostyrylamino)-1-(5-chlorobenzo[b]thiophen-3-yl)-2-oxoethylphosphonic acid::CHEMBL222952

SMILES: OP(O)(=O)C(C(=O)NC=Cc1ccc(F)cc1)c1csc2ccc(Cl)cc12

InChI Key: InChIKey=WYJAXLRHJUBHGU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50208239   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM50208239 ((E)-2-(4-fluorostyrylamino)-1-(5-chlorobenzo[b]thi...) Show SMILES OP(O)(=O)C(C(=O)NC=Cc1ccc(F)cc1)c1csc2ccc(Cl)cc12 |w:9.9| Show InChI InChI=1S/C18H14ClFNO4PS/c19-12-3-6-16-14(9-12)15(10-27-16)17(26(23,24)25)18(22)21-8-7-11-1-4-13(20)5-2-11/h1-10,17H,(H,21,22)(H2,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of human skin chymase				J Med Chem 50: 1727-30 (2007) Article DOI: 10.1021/jm0700619 BindingDB Entry DOI: 10.7270/Q26W99RF
					More data for this Ligand-Target Pair