BDBM50208241 (E)-1-(5-chlorobenzo[b]thiophen-3-yl)-2-oxo-2-(styrylamino)ethyl(methyl)phosphinic acid::CHEMBL222204

SMILES: CP(O)(=O)C(C(=O)NC=Cc1ccccc1)c1csc2ccc(Cl)cc12

InChI Key: InChIKey=DGWSMOPHIGQBQQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50208241   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM50208241 ((E)-1-(5-chlorobenzo[b]thiophen-3-yl)-2-oxo-2-(sty...) Show SMILES CP(O)(=O)C(C(=O)NC=Cc1ccccc1)c1csc2ccc(Cl)cc12 |w:9.9| Show InChI InChI=1S/C19H17ClNO3PS/c1-25(23,24)18(16-12-26-17-8-7-14(20)11-15(16)17)19(22)21-10-9-13-5-3-2-4-6-13/h2-12,18H,1H3,(H,21,22)(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of human skin chymase				J Med Chem 50: 1727-30 (2007) Article DOI: 10.1021/jm0700619 BindingDB Entry DOI: 10.7270/Q26W99RF
					More data for this Ligand-Target Pair