BDBM50210284 CHEMBL374690::N,N-dimethyl-2-(3-(5-(3-phenoxyprop-1-ynyl)thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazol-6-yloxy)acetamide

SMILES: CN(C)C(=O)COc1ccc-2c(Cc3c-2n[nH]c3-c2csc(c2)C#CCOc2ccccc2)c1

InChI Key: InChIKey=JXRNOMQKAQYKAL-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50210284   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50210284 (CHEMBL374690 | N,N-dimethyl-2-(3-(5-(3-phenoxyprop...) Show SMILES CN(C)C(=O)COc1ccc-2c(Cc3c-2n[nH]c3-c2csc(c2)C#CCOc2ccccc2)c1 Show InChI InChI=1S/C27H23N3O3S/c1-30(2)25(31)16-33-21-10-11-23-18(13-21)15-24-26(28-29-27(23)24)19-14-22(34-17-19)9-6-12-32-20-7-4-3-5-8-20/h3-5,7-8,10-11,13-14,17H,12,15-16H2,1-2H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot				J Med Chem 50: 2011-29 (2007) Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50210284 (CHEMBL374690 | N,N-dimethyl-2-(3-(5-(3-phenoxyprop...) Show SMILES CN(C)C(=O)COc1ccc-2c(Cc3c-2n[nH]c3-c2csc(c2)C#CCOc2ccccc2)c1 Show InChI InChI=1S/C27H23N3O3S/c1-30(2)25(31)16-33-21-10-11-23-18(13-21)15-24-26(28-29-27(23)24)19-14-22(34-17-19)9-6-12-32-20-7-4-3-5-8-20/h3-5,7-8,10-11,13-14,17H,12,15-16H2,1-2H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of hERG expressed in HEK293 cells assessed as effect on ionic current by patch clamp assay				J Med Chem 50: 2011-29 (2007) Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50210284 (CHEMBL374690 | N,N-dimethyl-2-(3-(5-(3-phenoxyprop...) Show SMILES CN(C)C(=O)COc1ccc-2c(Cc3c-2n[nH]c3-c2csc(c2)C#CCOc2ccccc2)c1 Show InChI InChI=1S/C27H23N3O3S/c1-30(2)25(31)16-33-21-10-11-23-18(13-21)15-24-26(28-29-27(23)24)19-14-22(34-17-19)9-6-12-32-20-7-4-3-5-8-20/h3-5,7-8,10-11,13-14,17H,12,15-16H2,1-2H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot				J Med Chem 50: 2011-29 (2007) Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0
					More data for this Ligand-Target Pair