BDBM50211001 6-(3-hydroxy-4-iodophenyl)-3-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)furo[2,3-d]pyrimidin-2(3H)-one::CHEMBL248320
SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1cc2cc(oc2nc1=O)-c1ccc(I)c(O)c1
InChI Key: InChIKey=NGNSMZWUMDNDPL-NWANDNLSSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thymidine kinase (Varicella-zoster virus (strain Dumas) (HHV-3) (Hum...) | BDBM50211001 (6-(3-hydroxy-4-iodophenyl)-3-((2R,4S,5R)-4-hydroxy...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Katholieke Universiteit Leuven Curated by ChEMBL | Assay Description Inhibition of VZV thymidine kinase | Bioorg Med Chem Lett 17: 3458-62 (2007) Article DOI: 10.1016/j.bmcl.2007.03.081 BindingDB Entry DOI: 10.7270/Q2V40TVW | |||||||||||
More data for this Ligand-Target Pair |