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SMILES: Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc\c2=N/NC(N)=O)C1CC1

InChI Key: InChIKey=IBDCELZVSPWUMM-PCLIKHOPSA-N

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50212753   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha/2-beta


(Homo sapiens (Human))		BDBM50212753
PNG
(CHEMBL262982)
Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc\c2=N/NC(N)=O)C1CC1
Show InChI InChI=1S/C20H19F2N5O/c1-10-7-12(8-11(2)24-10)17-15(21)9-14-16(25-26-20(23)28)5-6-27(13-3-4-13)19(14)18(17)22/h5-9,13H,3-4H2,1-2H3,(H3,23,26,28)/b25-16+
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
n/an/an/an/a 3.10E+3n/an/an/an/a


TBA

Assay Description
Inhibitory activity in a cell-free assay of DNA cleavage mediated by purified HeLa cell topoisomerase II.

Citation and Details

BindingDB Entry DOI: 10.7270/Q2R49SXV
More data for this
Ligand-Target Pair