BindingDB logo
myBDB logout

null

SMILES: Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc\c2=N/c1ccccc1O)C1CC1

InChI Key: InChIKey=LEAZIPJRHQLPNZ-ZTKZIYFRSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50212858   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha/2-beta


(Homo sapiens (Human))		BDBM50212858
PNG
(CHEMBL422791)
Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc\c2=N/c1ccccc1O)C1CC1
Show InChI InChI=1S/C25H21F2N3O/c1-14-11-16(12-15(2)28-14)23-19(26)13-18-20(29-21-5-3-4-6-22(21)31)9-10-30(17-7-8-17)25(18)24(23)27/h3-6,9-13,17,31H,7-8H2,1-2H3/b29-20+
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
n/an/an/an/a 1.60E+3n/an/an/an/a


TBA

Assay Description
Inhibitory activity in a cell-free assay of DNA cleavage mediated by purified HeLa cell topoisomerase II.

Citation and Details

BindingDB Entry DOI: 10.7270/Q2R49SXV
More data for this
Ligand-Target Pair