BDBM50213294 CHEMBL8063

SMILES: Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(Cc1ncc[nH]1)c2=O)C1CC1

InChI Key: InChIKey=MEIYMOMJZSSDSS-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50213294   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 2-alpha/2-beta (Homo sapiens (Human))	BDBM50213294 (CHEMBL8063) Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(Cc1ncc[nH]1)c2=O)C1CC1 Show InChI InChI=1S/C23H20F2N4O/c1-12-7-14(8-13(2)28-12)20-18(24)10-17-22(21(20)25)29(16-3-4-16)11-15(23(17)30)9-19-26-5-6-27-19/h5-8,10-11,16H,3-4,9H2,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars		n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against HeLa cell Topoisomerase II				Citation and Details BindingDB Entry DOI: 10.7270/Q2TX3HJW
					More data for this Ligand-Target Pair