Found 4 hits for monomerid = 50213954 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Matrix metalloproteinase-14 (MMP14)
(Homo sapiens (Human)) | BDBM50213954
(3-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydr...)Show SMILES CCC(C)C(=O)N1CCCC(CS(=O)(=O)c2ccc(OCC#CC)cc2)(C1)C(=O)NO |w:10.10,2.2| Show InChI InChI=1S/C22H30N2O6S/c1-4-6-14-30-18-8-10-19(11-9-18)31(28,29)16-22(21(26)23-27)12-7-13-24(15-22)20(25)17(3)5-2/h8-11,17,27H,5,7,12-16H2,1-3H3,(H,23,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of MMP14 |
Bioorg Med Chem Lett 17: 4333-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.022 BindingDB Entry DOI: 10.7270/Q2CN73K3 |
More data for this Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50213954
(3-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydr...)Show SMILES CCC(C)C(=O)N1CCCC(CS(=O)(=O)c2ccc(OCC#CC)cc2)(C1)C(=O)NO |w:10.10,2.2| Show InChI InChI=1S/C22H30N2O6S/c1-4-6-14-30-18-8-10-19(11-9-18)31(28,29)16-22(21(26)23-27)12-7-13-24(15-22)20(25)17(3)5-2/h8-11,17,27H,5,7,12-16H2,1-3H3,(H,23,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of MMP13 |
Bioorg Med Chem Lett 17: 4333-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.022 BindingDB Entry DOI: 10.7270/Q2CN73K3 |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50213954
(3-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydr...)Show SMILES CCC(C)C(=O)N1CCCC(CS(=O)(=O)c2ccc(OCC#CC)cc2)(C1)C(=O)NO |w:10.10,2.2| Show InChI InChI=1S/C22H30N2O6S/c1-4-6-14-30-18-8-10-19(11-9-18)31(28,29)16-22(21(26)23-27)12-7-13-24(15-22)20(25)17(3)5-2/h8-11,17,27H,5,7,12-16H2,1-3H3,(H,23,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of MMP2 |
Bioorg Med Chem Lett 17: 4333-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.022 BindingDB Entry DOI: 10.7270/Q2CN73K3 |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50213954
(3-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydr...)Show SMILES CCC(C)C(=O)N1CCCC(CS(=O)(=O)c2ccc(OCC#CC)cc2)(C1)C(=O)NO |w:10.10,2.2| Show InChI InChI=1S/C22H30N2O6S/c1-4-6-14-30-18-8-10-19(11-9-18)31(28,29)16-22(21(26)23-27)12-7-13-24(15-22)20(25)17(3)5-2/h8-11,17,27H,5,7,12-16H2,1-3H3,(H,23,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of TACE by FRET assay |
Bioorg Med Chem Lett 17: 4333-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.022 BindingDB Entry DOI: 10.7270/Q2CN73K3 |
More data for this Ligand-Target Pair | |