BDBM50214436 CHEMBL389688::octanedioic acid {2'-[2-amino-3-(1H-indol-3-yl)propionylamino]biphenyl-4-yl}amide hydroxyamide

SMILES: N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccccc1-c1ccc(NC(=O)CCCCCCC(=O)NO)cc1

InChI Key: InChIKey=ACGVFMBQNSCSQI-SANMLTNESA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50214436   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50214436 (CHEMBL389688 | octanedioic acid {2'-[2-amino-3-(1H...) Show SMILES N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccccc1-c1ccc(NC(=O)CCCCCCC(=O)NO)cc1 Show InChI InChI=1S/C31H35N5O4/c32-26(19-22-20-33-27-11-7-5-10-25(22)27)31(39)35-28-12-8-6-9-24(28)21-15-17-23(18-16-21)34-29(37)13-3-1-2-4-14-30(38)36-40/h5-12,15-18,20,26,33,40H,1-4,13-14,19,32H2,(H,34,37)(H,35,39)(H,36,38)/t26-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.72E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of His-tagged HDAC8 expressed in Sf9 cells by fluorescence-based assay				J Med Chem 50: 3054-61 (2007) Article DOI: 10.1021/jm070178x BindingDB Entry DOI: 10.7270/Q26W99SW
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50214436 (CHEMBL389688 | octanedioic acid {2'-[2-amino-3-(1H...) Show SMILES N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccccc1-c1ccc(NC(=O)CCCCCCC(=O)NO)cc1 Show InChI InChI=1S/C31H35N5O4/c32-26(19-22-20-33-27-11-7-5-10-25(22)27)31(39)35-28-12-8-6-9-24(28)21-15-17-23(18-16-21)34-29(37)13-3-1-2-4-14-30(38)36-40/h5-12,15-18,20,26,33,40H,1-4,13-14,19,32H2,(H,34,37)(H,35,39)(H,36,38)/t26-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	167	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of His-tagged HDAC2 expressed in Sf9 cells by fluorescence-based assay				J Med Chem 50: 3054-61 (2007) Article DOI: 10.1021/jm070178x BindingDB Entry DOI: 10.7270/Q26W99SW
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50214436 (CHEMBL389688 | octanedioic acid {2'-[2-amino-3-(1H...) Show SMILES N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccccc1-c1ccc(NC(=O)CCCCCCC(=O)NO)cc1 Show InChI InChI=1S/C31H35N5O4/c32-26(19-22-20-33-27-11-7-5-10-25(22)27)31(39)35-28-12-8-6-9-24(28)21-15-17-23(18-16-21)34-29(37)13-3-1-2-4-14-30(38)36-40/h5-12,15-18,20,26,33,40H,1-4,13-14,19,32H2,(H,34,37)(H,35,39)(H,36,38)/t26-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	26.7	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of His-tagged HDAC1 expressed in Sf9 cells by fluorescence-based assay				J Med Chem 50: 3054-61 (2007) Article DOI: 10.1021/jm070178x BindingDB Entry DOI: 10.7270/Q26W99SW
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50214436 (CHEMBL389688 | octanedioic acid {2'-[2-amino-3-(1H...) Show SMILES N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccccc1-c1ccc(NC(=O)CCCCCCC(=O)NO)cc1 Show InChI InChI=1S/C31H35N5O4/c32-26(19-22-20-33-27-11-7-5-10-25(22)27)31(39)35-28-12-8-6-9-24(28)21-15-17-23(18-16-21)34-29(37)13-3-1-2-4-14-30(38)36-40/h5-12,15-18,20,26,33,40H,1-4,13-14,19,32H2,(H,34,37)(H,35,39)(H,36,38)/t26-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of His-tagged HDAC6 expressed in Sf9 cells by fluorescence-based assay				J Med Chem 50: 3054-61 (2007) Article DOI: 10.1021/jm070178x BindingDB Entry DOI: 10.7270/Q26W99SW
					More data for this Ligand-Target Pair
Histone deacetylase 10 (Homo sapiens (Human))	BDBM50214436 (CHEMBL389688 | octanedioic acid {2'-[2-amino-3-(1H...) Show SMILES N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccccc1-c1ccc(NC(=O)CCCCCCC(=O)NO)cc1 Show InChI InChI=1S/C31H35N5O4/c32-26(19-22-20-33-27-11-7-5-10-25(22)27)31(39)35-28-12-8-6-9-24(28)21-15-17-23(18-16-21)34-29(37)13-3-1-2-4-14-30(38)36-40/h5-12,15-18,20,26,33,40H,1-4,13-14,19,32H2,(H,34,37)(H,35,39)(H,36,38)/t26-/m0/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	28.3	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of His-tagged HDAC10 expressed in Sf9 cells by fluorescence-based assay				J Med Chem 50: 3054-61 (2007) Article DOI: 10.1021/jm070178x BindingDB Entry DOI: 10.7270/Q26W99SW
					More data for this Ligand-Target Pair