BDBM50214918 5-[1-biphenyl-2-yl-meth-(Z)-ylidene]-10-methoxy-2,2,4-trimethyl-2,4a,5,12a-tetrahydro-1H-6-oxa-1-aza-chrysen-9-ol::CHEMBL231757

SMILES: COc1c(O)ccc2O\C(=C/c3ccccc3-c3ccccc3)C3=C(C=CC4NC(C)(C)C=C(C)C34)c12

InChI Key: InChIKey=PHIKTZJVOVUJJS-VEILYXNESA-N

Data: 1 KI  2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50214918   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50214918 (5-[1-biphenyl-2-yl-meth-(Z)-ylidene]-10-methoxy-2,...) Show SMILES COc1c(O)ccc2O\C(=C/c3ccccc3-c3ccccc3)C3=C(C=CC4NC(C)(C)C=C(C)C34)c12 |w:27.28,35.37,c:27,t:25,34| Show InChI InChI=1S/C33H31NO3/c1-20-19-33(2,3)34-25-15-14-24-30(29(20)25)28(37-27-17-16-26(35)32(36-4)31(24)27)18-22-12-8-9-13-23(22)21-10-6-5-7-11-21/h5-19,25,29,34-35H,1-4H3/b28-18-	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of radiolabeled dexamethasone from glucocorticoid receptor				Bioorg Med Chem Lett 17: 4158-62 (2007) Article DOI: 10.1016/j.bmcl.2007.05.062 BindingDB Entry DOI: 10.7270/Q2DF6QXW
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50214918 (5-[1-biphenyl-2-yl-meth-(Z)-ylidene]-10-methoxy-2,...) Show SMILES COc1c(O)ccc2O\C(=C/c3ccccc3-c3ccccc3)C3=C(C=CC4NC(C)(C)C=C(C)C34)c12 |w:27.28,35.37,c:27,t:25,34| Show InChI InChI=1S/C33H31NO3/c1-20-19-33(2,3)34-25-15-14-24-30(29(20)25)28(37-27-17-16-26(35)32(36-4)31(24)27)18-22-12-8-9-13-23(22)21-10-6-5-7-11-21/h5-19,25,29,34-35H,1-4H3/b28-18-	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at GR by GRE activation assay				Bioorg Med Chem Lett 17: 4158-62 (2007) Article DOI: 10.1016/j.bmcl.2007.05.062 BindingDB Entry DOI: 10.7270/Q2DF6QXW
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50214918 (5-[1-biphenyl-2-yl-meth-(Z)-ylidene]-10-methoxy-2,...) Show SMILES COc1c(O)ccc2O\C(=C/c3ccccc3-c3ccccc3)C3=C(C=CC4NC(C)(C)C=C(C)C34)c12 |w:27.28,35.37,c:27,t:25,34| Show InChI InChI=1S/C33H31NO3/c1-20-19-33(2,3)34-25-15-14-24-30(29(20)25)28(37-27-17-16-26(35)32(36-4)31(24)27)18-22-12-8-9-13-23(22)21-10-6-5-7-11-21/h5-19,25,29,34-35H,1-4H3/b28-18-	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at GR assessed as inhibition of dexamethasone-induced GRE activation				Bioorg Med Chem Lett 17: 4158-62 (2007) Article DOI: 10.1016/j.bmcl.2007.05.062 BindingDB Entry DOI: 10.7270/Q2DF6QXW
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50214918 (5-[1-biphenyl-2-yl-meth-(Z)-ylidene]-10-methoxy-2,...) Show SMILES COc1c(O)ccc2O\C(=C/c3ccccc3-c3ccccc3)C3=C(C=CC4NC(C)(C)C=C(C)C34)c12 |w:27.28,35.37,c:27,t:25,34| Show InChI InChI=1S/C33H31NO3/c1-20-19-33(2,3)34-25-15-14-24-30(29(20)25)28(37-27-17-16-26(35)32(36-4)31(24)27)18-22-12-8-9-13-23(22)21-10-6-5-7-11-21/h5-19,25,29,34-35H,1-4H3/b28-18-	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Activity at GR assessed as repression of TNFalpha and IL 1beta induced E-selectin response				Bioorg Med Chem Lett 17: 4158-62 (2007) Article DOI: 10.1016/j.bmcl.2007.05.062 BindingDB Entry DOI: 10.7270/Q2DF6QXW
					More data for this Ligand-Target Pair