BDBM50216410 CHEMBL390888::isoquinolinesulfon-5-yl-{2-[4-(4-chlorobenzyl)piperazin-1-yl]-2-oxoethyl}amide

SMILES: Clc1ccc(CN2CCN(CC2)C(=O)CNS(=O)(=O)c2cccc3cnccc23)cc1

InChI Key: InChIKey=ULMNKFMCEDGIDJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50216410   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50216410 (CHEMBL390888 | isoquinolinesulfon-5-yl-{2-[4-(4-ch...) Show SMILES Clc1ccc(CN2CCN(CC2)C(=O)CNS(=O)(=O)c2cccc3cnccc23)cc1 Show InChI InChI=1S/C22H23ClN4O3S/c23-19-6-4-17(5-7-19)16-26-10-12-27(13-11-26)22(28)15-25-31(29,30)21-3-1-2-18-14-24-9-8-20(18)21/h1-9,14,25H,10-13,15-16H2	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Università di Ferrara Curated by ChEMBL					Assay Description Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as effect on intracellular calcium influx				J Med Chem 50: 3706-15 (2007) Article DOI: 10.1021/jm070443e BindingDB Entry DOI: 10.7270/Q2PN95CS
					More data for this Ligand-Target Pair