BDBM50216690 2-cyano-3-(5-(2,3-dichlorophenyl)furan-2-yl)-N-(quinolin-8-yl)acrylamide::CHEMBL226027

SMILES: Clc1cccc(-c2ccc(\C=C(/C#N)C(=O)Nc3cccc4cccnc34)o2)c1Cl

InChI Key: InChIKey=GAPBGBBBGOGLTD-NTCAYCPXSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50216690   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NAD-dependent deacetylase sirtuin 2 (Homo sapiens (Human))	BDBM50216690 (2-cyano-3-(5-(2,3-dichlorophenyl)furan-2-yl)-N-(qu...) Show SMILES Clc1cccc(-c2ccc(\C=C(/C#N)C(=O)Nc3cccc4cccnc34)o2)c1Cl Show InChI InChI=1S/C23H13Cl2N3O2/c24-18-7-2-6-17(21(18)25)20-10-9-16(30-20)12-15(13-26)23(29)28-19-8-1-4-14-5-3-11-27-22(14)19/h1-12H,(H,28,29)/b15-12+	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of human recombinant SIRT2 using fluorescent peptide substrate by fluorescent assay				Science 317: 516-9 (2007) Article DOI: 10.1126/science.1143780 BindingDB Entry DOI: 10.7270/Q2D50MPG
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3 (SIRT3) (Homo sapiens (Human))	BDBM50216690 (2-cyano-3-(5-(2,3-dichlorophenyl)furan-2-yl)-N-(qu...) Show SMILES Clc1cccc(-c2ccc(\C=C(/C#N)C(=O)Nc3cccc4cccnc34)o2)c1Cl Show InChI InChI=1S/C23H13Cl2N3O2/c24-18-7-2-6-17(21(18)25)20-10-9-16(30-20)12-15(13-26)23(29)28-19-8-1-4-14-5-3-11-27-22(14)19/h1-12H,(H,28,29)/b15-12+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of human recombinant SIRT3 using fluorescent peptide substrate by fluorescent assay				Science 317: 516-9 (2007) Article DOI: 10.1126/science.1143780 BindingDB Entry DOI: 10.7270/Q2D50MPG
					More data for this Ligand-Target Pair
NAD-Dependent Deacetylase Sirtuin-1 (Homo sapiens (Human))	BDBM50216690 (2-cyano-3-(5-(2,3-dichlorophenyl)furan-2-yl)-N-(qu...) Show SMILES Clc1cccc(-c2ccc(\C=C(/C#N)C(=O)Nc3cccc4cccnc34)o2)c1Cl Show InChI InChI=1S/C23H13Cl2N3O2/c24-18-7-2-6-17(21(18)25)20-10-9-16(30-20)12-15(13-26)23(29)28-19-8-1-4-14-5-3-11-27-22(14)19/h1-12H,(H,28,29)/b15-12+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of human recombinant SIRT1 using fluorescent peptide substrate by fluorescent assay				Science 317: 516-9 (2007) Article DOI: 10.1126/science.1143780 BindingDB Entry DOI: 10.7270/Q2D50MPG
					More data for this Ligand-Target Pair