BDBM50217447 CHEMBL242257::cis-1-adamantan-1-yl-3-(4-hydroxycyclohexyl)urea

SMILES: O[C@H]1CC[C@H](CC1)NC(=O)NC12CC3CC(CC(C3)C1)C2

InChI Key: InChIKey=YHZXOUHNBSOYQD-PIYFJZFMSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50217447   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM50217447 (CHEMBL242257 | cis-1-adamantan-1-yl-3-(4-hydroxycy...) Show SMILES O[C@H]1CC[C@H](CC1)NC(=O)NC12CC3CC(CC(C3)C1)C2 |wD:4.7,1.0,TLB:10:11:14.13.18:16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11,10:11:14:18.17.16,(27.11,6.8,;26.39,5.44,;24.85,5.38,;24.12,4.02,;24.94,2.73,;26.49,2.78,;27.21,4.14,;24.23,1.36,;22.69,1.3,;21.87,2.6,;21.97,-.06,;20.43,-.12,;19.42,-1.4,;18.01,-.84,;16.51,-1.26,;17.71,.02,;17.7,1.51,;19.05,1.98,;18.01,.75,;20.45,1.4,;19.04,-.47,)| Show InChI InChI=1S/C17H28N2O2/c20-15-3-1-14(2-4-15)18-16(21)19-17-8-11-5-12(9-17)7-13(6-11)10-17/h11-15,20H,1-10H2,(H2,18,19,21)/t11?,12?,13?,14-,15+,17?	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
University of California-Davis Curated by ChEMBL					Assay Description Inhibition of human recombinant soluble epoxide hydrolase				J Med Chem 50: 3825-40 (2007) Article DOI: 10.1021/jm070270t BindingDB Entry DOI: 10.7270/Q2TQ62BW
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