Found 13 hits for monomerid = 50218282 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50218282
((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)Show SMILES CCOC(=O)N1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-2-34-24(33)28-13-17(18(14-28)27-23(32)19-10-11-20(25)35-19)26-22(31)15-6-8-16(9-7-15)29-12-4-3-5-21(29)30/h3-12,17-18H,2,13-14H2,1H3,(H,26,31)(H,27,32)/t17-,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description Inhibition of human factor 10a |
Bioorg Med Chem Lett 17: 5041-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50218282
((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)Show SMILES CCOC(=O)N1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-2-34-24(33)28-13-17(18(14-28)27-23(32)19-10-11-20(25)35-19)26-22(31)15-6-8-16(9-7-15)29-12-4-3-5-21(29)30/h3-12,17-18H,2,13-14H2,1H3,(H,26,31)(H,27,32)/t17-,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.730 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description Inhibition of human factor 10a in presence of tripeptide substrate at 25 degC |
Bioorg Med Chem Lett 17: 5041-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50218282
((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)Show SMILES CCOC(=O)N1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-2-34-24(33)28-13-17(18(14-28)27-23(32)19-10-11-20(25)35-19)26-22(31)15-6-8-16(9-7-15)29-12-4-3-5-21(29)30/h3-12,17-18H,2,13-14H2,1H3,(H,26,31)(H,27,32)/t17-,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description Inhibition of human factor 10a in presence of tripeptide substrate at 37 degC |
Bioorg Med Chem Lett 17: 5041-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50218282
((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)Show SMILES CCOC(=O)N1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-2-34-24(33)28-13-17(18(14-28)27-23(32)19-10-11-20(25)35-19)26-22(31)15-6-8-16(9-7-15)29-12-4-3-5-21(29)30/h3-12,17-18H,2,13-14H2,1H3,(H,26,31)(H,27,32)/t17-,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description Inhibition of human factor 10a in presence of prothrombin at 25 degC |
Bioorg Med Chem Lett 17: 5041-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50218282
((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)Show SMILES CCOC(=O)N1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-2-34-24(33)28-13-17(18(14-28)27-23(32)19-10-11-20(25)35-19)26-22(31)15-6-8-16(9-7-15)29-12-4-3-5-21(29)30/h3-12,17-18H,2,13-14H2,1H3,(H,26,31)(H,27,32)/t17-,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description Inhibition of human factor 10a in presence of saturating prothrombin at 37 degC |
Bioorg Med Chem Lett 17: 5041-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ |
More data for this Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50218282
((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)Show SMILES CCOC(=O)N1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-2-34-24(33)28-13-17(18(14-28)27-23(32)19-10-11-20(25)35-19)26-22(31)15-6-8-16(9-7-15)29-12-4-3-5-21(29)30/h3-12,17-18H,2,13-14H2,1H3,(H,26,31)(H,27,32)/t17-,18+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 4.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description Inhibition of human thrombin |
Bioorg Med Chem Lett 17: 5041-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ |
More data for this Ligand-Target Pair | |
Plasma kallikrein
(Homo sapiens (Human)) | BDBM50218282
((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)Show SMILES CCOC(=O)N1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-2-34-24(33)28-13-17(18(14-28)27-23(32)19-10-11-20(25)35-19)26-22(31)15-6-8-16(9-7-15)29-12-4-3-5-21(29)30/h3-12,17-18H,2,13-14H2,1H3,(H,26,31)(H,27,32)/t17-,18+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description Inhibition of human plasma kallikrein |
Bioorg Med Chem Lett 17: 5041-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ |
More data for this Ligand-Target Pair | |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50218282
((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)Show SMILES CCOC(=O)N1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-2-34-24(33)28-13-17(18(14-28)27-23(32)19-10-11-20(25)35-19)26-22(31)15-6-8-16(9-7-15)29-12-4-3-5-21(29)30/h3-12,17-18H,2,13-14H2,1H3,(H,26,31)(H,27,32)/t17-,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 7.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description Inhibition of human factor 11a |
Bioorg Med Chem Lett 17: 5041-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ |
More data for this Ligand-Target Pair | |
Coagulation factor VII
(Homo sapiens (Human)) | BDBM50218282
((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)Show SMILES CCOC(=O)N1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-2-34-24(33)28-13-17(18(14-28)27-23(32)19-10-11-20(25)35-19)26-22(31)15-6-8-16(9-7-15)29-12-4-3-5-21(29)30/h3-12,17-18H,2,13-14H2,1H3,(H,26,31)(H,27,32)/t17-,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description Inhibition of human factor 7a |
Bioorg Med Chem Lett 17: 5041-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ |
More data for this Ligand-Target Pair | |
Urokinase-type plasminogen activator
(Homo sapiens (Human)) | BDBM50218282
((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)Show SMILES CCOC(=O)N1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-2-34-24(33)28-13-17(18(14-28)27-23(32)19-10-11-20(25)35-19)26-22(31)15-6-8-16(9-7-15)29-12-4-3-5-21(29)30/h3-12,17-18H,2,13-14H2,1H3,(H,26,31)(H,27,32)/t17-,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description Inhibition of human urokinase |
Bioorg Med Chem Lett 17: 5041-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ |
More data for this Ligand-Target Pair | |
Vitamin K-dependent protein C
(Homo sapiens (Human)) | BDBM50218282
((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)Show SMILES CCOC(=O)N1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-2-34-24(33)28-13-17(18(14-28)27-23(32)19-10-11-20(25)35-19)26-22(31)15-6-8-16(9-7-15)29-12-4-3-5-21(29)30/h3-12,17-18H,2,13-14H2,1H3,(H,26,31)(H,27,32)/t17-,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description Inhibition of human activated protein C |
Bioorg Med Chem Lett 17: 5041-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ |
More data for this Ligand-Target Pair | |
Tissue-type plasminogen activator
(Homo sapiens (Human)) | BDBM50218282
((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)Show SMILES CCOC(=O)N1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-2-34-24(33)28-13-17(18(14-28)27-23(32)19-10-11-20(25)35-19)26-22(31)15-6-8-16(9-7-15)29-12-4-3-5-21(29)30/h3-12,17-18H,2,13-14H2,1H3,(H,26,31)(H,27,32)/t17-,18+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description Inhibition of human tissue plasminogen activator |
Bioorg Med Chem Lett 17: 5041-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50218282
((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)Show SMILES CCOC(=O)N1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-2-34-24(33)28-13-17(18(14-28)27-23(32)19-10-11-20(25)35-19)26-22(31)15-6-8-16(9-7-15)29-12-4-3-5-21(29)30/h3-12,17-18H,2,13-14H2,1H3,(H,26,31)(H,27,32)/t17-,18+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description Inhibition of human Plasmin |
Bioorg Med Chem Lett 17: 5041-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ |
More data for this Ligand-Target Pair | |