BDBM50218287 (1S,3R,4S)-3-(2-chlorothiophene-5-carboxamido)-4-(4-(2-oxopyridin-1(2H)-yl)benzamido)cyclopentanecarboxylic acid::CHEMBL401235

SMILES: OC(=O)[C@@H]1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O

InChI Key: InChIKey=YCMDRFHFKJJFQF-BHYGNILZSA-N

Data: 9 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50218287   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor X (Homo sapiens (Human))	BDBM50218287 ((1S,3R,4S)-3-(2-chlorothiophene-5-carboxamido)-4-(...) Show SMILES OC(=O)[C@@H]1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C23H20ClN3O5S/c24-19-9-8-18(33-19)22(30)26-17-12-14(23(31)32)11-16(17)25-21(29)13-4-6-15(7-5-13)27-10-2-1-3-20(27)28/h1-10,14,16-17H,11-12H2,(H,25,29)(H,26,30)(H,31,32)/t14-,16-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human factor 10a				Bioorg Med Chem Lett 17: 5041-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50218287 ((1S,3R,4S)-3-(2-chlorothiophene-5-carboxamido)-4-(...) Show SMILES OC(=O)[C@@H]1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C23H20ClN3O5S/c24-19-9-8-18(33-19)22(30)26-17-12-14(23(31)32)11-16(17)25-21(29)13-4-6-15(7-5-13)27-10-2-1-3-20(27)28/h1-10,14,16-17H,11-12H2,(H,25,29)(H,26,30)(H,31,32)/t14-,16-,17+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human plasma kallikrein				Bioorg Med Chem Lett 17: 5041-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ
					More data for this Ligand-Target Pair
Coagulation factor VII (Homo sapiens (Human))	BDBM50218287 ((1S,3R,4S)-3-(2-chlorothiophene-5-carboxamido)-4-(...) Show SMILES OC(=O)[C@@H]1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C23H20ClN3O5S/c24-19-9-8-18(33-19)22(30)26-17-12-14(23(31)32)11-16(17)25-21(29)13-4-6-15(7-5-13)27-10-2-1-3-20(27)28/h1-10,14,16-17H,11-12H2,(H,25,29)(H,26,30)(H,31,32)/t14-,16-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human factor 7a				Bioorg Med Chem Lett 17: 5041-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ
					More data for this Ligand-Target Pair
Coagulation factor XI (Homo sapiens (Human))	BDBM50218287 ((1S,3R,4S)-3-(2-chlorothiophene-5-carboxamido)-4-(...) Show SMILES OC(=O)[C@@H]1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C23H20ClN3O5S/c24-19-9-8-18(33-19)22(30)26-17-12-14(23(31)32)11-16(17)25-21(29)13-4-6-15(7-5-13)27-10-2-1-3-20(27)28/h1-10,14,16-17H,11-12H2,(H,25,29)(H,26,30)(H,31,32)/t14-,16-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human factor 11a				Bioorg Med Chem Lett 17: 5041-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50218287 ((1S,3R,4S)-3-(2-chlorothiophene-5-carboxamido)-4-(...) Show SMILES OC(=O)[C@@H]1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C23H20ClN3O5S/c24-19-9-8-18(33-19)22(30)26-17-12-14(23(31)32)11-16(17)25-21(29)13-4-6-15(7-5-13)27-10-2-1-3-20(27)28/h1-10,14,16-17H,11-12H2,(H,25,29)(H,26,30)(H,31,32)/t14-,16-,17+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human thrombin				Bioorg Med Chem Lett 17: 5041-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50218287 ((1S,3R,4S)-3-(2-chlorothiophene-5-carboxamido)-4-(...) Show SMILES OC(=O)[C@@H]1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C23H20ClN3O5S/c24-19-9-8-18(33-19)22(30)26-17-12-14(23(31)32)11-16(17)25-21(29)13-4-6-15(7-5-13)27-10-2-1-3-20(27)28/h1-10,14,16-17H,11-12H2,(H,25,29)(H,26,30)(H,31,32)/t14-,16-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human urokinase				Bioorg Med Chem Lett 17: 5041-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ
					More data for this Ligand-Target Pair
Vitamin K-dependent protein C (Homo sapiens (Human))	BDBM50218287 ((1S,3R,4S)-3-(2-chlorothiophene-5-carboxamido)-4-(...) Show SMILES OC(=O)[C@@H]1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C23H20ClN3O5S/c24-19-9-8-18(33-19)22(30)26-17-12-14(23(31)32)11-16(17)25-21(29)13-4-6-15(7-5-13)27-10-2-1-3-20(27)28/h1-10,14,16-17H,11-12H2,(H,25,29)(H,26,30)(H,31,32)/t14-,16-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human activated protein C				Bioorg Med Chem Lett 17: 5041-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50218287 ((1S,3R,4S)-3-(2-chlorothiophene-5-carboxamido)-4-(...) Show SMILES OC(=O)[C@@H]1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C23H20ClN3O5S/c24-19-9-8-18(33-19)22(30)26-17-12-14(23(31)32)11-16(17)25-21(29)13-4-6-15(7-5-13)27-10-2-1-3-20(27)28/h1-10,14,16-17H,11-12H2,(H,25,29)(H,26,30)(H,31,32)/t14-,16-,17+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human tissue plasminogen activator				Bioorg Med Chem Lett 17: 5041-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50218287 ((1S,3R,4S)-3-(2-chlorothiophene-5-carboxamido)-4-(...) Show SMILES OC(=O)[C@@H]1C[C@@H](NC(=O)c2ccc(Cl)s2)[C@H](C1)NC(=O)c1ccc(cc1)-n1ccccc1=O Show InChI InChI=1S/C23H20ClN3O5S/c24-19-9-8-18(33-19)22(30)26-17-12-14(23(31)32)11-16(17)25-21(29)13-4-6-15(7-5-13)27-10-2-1-3-20(27)28/h1-10,14,16-17H,11-12H2,(H,25,29)(H,26,30)(H,31,32)/t14-,16-,17+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human Plasmin				Bioorg Med Chem Lett 17: 5041-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.020 BindingDB Entry DOI: 10.7270/Q23J3CPQ
					More data for this Ligand-Target Pair