BDBM50218365 CHEMBL391666::N1-{5-[7-[(Z)-1-(2-chlorophenyl)methylidene]-6-(2,4-dichloro-5-fluorophenyl)-7H-[1,2,4]triazolo[3,4-b]-[1,3,4]thiadiazin-3-yl]-4-methyl-2-thienyl}-2-chloroacetamide

SMILES: Cc1cc(NC(=O)CCl)sc1-c1nnc2S\C(=C/c3ccccc3Cl)C(=Nn12)c1cc(F)c(Cl)cc1Cl

InChI Key: InChIKey=DLLHBSCJYVRSNB-WSVATBPTSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50218365   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM50218365 (CHEMBL391666 | N1-{5-[7-[(Z)-1-(2-chlorophenyl)met...) Show SMILES Cc1cc(NC(=O)CCl)sc1-c1nnc2S\C(=C/c3ccccc3Cl)C(=Nn12)c1cc(F)c(Cl)cc1Cl |c:27| Show InChI InChI=1S/C24H14Cl4FN5OS2/c1-11-6-20(30-19(35)10-25)37-22(11)23-31-32-24-34(23)33-21(13-8-17(29)16(28)9-15(13)27)18(36-24)7-12-4-2-3-5-14(12)26/h2-9H,10H2,1H3,(H,30,35)/b18-7-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dr. Reddy's Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Cdk5/p25				Bioorg Med Chem 15: 6397-406 (2007) Article DOI: 10.1016/j.bmc.2007.06.053 BindingDB Entry DOI: 10.7270/Q2JS9RP0
					More data for this Ligand-Target Pair