BDBM50218704 3-(4-amino-3-methoxy-phenyl)-7-morpholin-4-yl-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one::CHEMBL243721

SMILES: COc1cc(ccc1N)-c1ccc2c(Nc3cc(ccc3NC2=O)N2CCOCC2)c1

InChI Key: InChIKey=ZVVZHIBPLVZQPC-UHFFFAOYSA-N

Data: 1 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50218704   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50218704 (3-(4-amino-3-methoxy-phenyl)-7-morpholin-4-yl-5,10...) Show SMILES COc1cc(ccc1N)-c1ccc2c(Nc3cc(ccc3NC2=O)N2CCOCC2)c1 Show InChI InChI=1S/C24H24N4O3/c1-30-23-13-16(3-6-19(23)25)15-2-5-18-21(12-15)26-22-14-17(28-8-10-31-11-9-28)4-7-20(22)27-24(18)29/h2-7,12-14,26H,8-11,25H2,1H3,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant Chk1				J Med Chem 50: 4162-76 (2007) Article DOI: 10.1021/jm070105d BindingDB Entry DOI: 10.7270/Q22J6BKS
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50218704 (3-(4-amino-3-methoxy-phenyl)-7-morpholin-4-yl-5,10...) Show SMILES COc1cc(ccc1N)-c1ccc2c(Nc3cc(ccc3NC2=O)N2CCOCC2)c1 Show InChI InChI=1S/C24H24N4O3/c1-30-23-13-16(3-6-19(23)25)15-2-5-18-21(12-15)26-22-14-17(28-8-10-31-11-9-28)4-7-20(22)27-24(18)29/h2-7,12-14,26H,8-11,25H2,1H3,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antiproliferative activity against HeLa cells by MTS assay				J Med Chem 50: 4162-76 (2007) Article DOI: 10.1021/jm070105d BindingDB Entry DOI: 10.7270/Q22J6BKS
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50218704 (3-(4-amino-3-methoxy-phenyl)-7-morpholin-4-yl-5,10...) Show SMILES COc1cc(ccc1N)-c1ccc2c(Nc3cc(ccc3NC2=O)N2CCOCC2)c1 Show InChI InChI=1S/C24H24N4O3/c1-30-23-13-16(3-6-19(23)25)15-2-5-18-21(12-15)26-22-14-17(28-8-10-31-11-9-28)4-7-20(22)27-24(18)29/h2-7,12-14,26H,8-11,25H2,1H3,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.61E+4	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antiproliferative activity against HeLa cells by MTS assay				J Med Chem 50: 4162-76 (2007) Article DOI: 10.1021/jm070105d BindingDB Entry DOI: 10.7270/Q22J6BKS
					More data for this Ligand-Target Pair