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BDBM50218987 CHEMBL56327

SMILES: CCCCN(C)C(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)Cc1ccc(F)cc1

InChI Key: InChIKey=KGZQTRVMNLJDEO-DQEYMECFSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50218987   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM50218987
PNG
(CHEMBL56327)
Show SMILES CCCCN(C)C(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)Cc1ccc(F)cc1
Show InChI InChI=1S/C28H44FN3O3/c1-5-6-16-32(4)28(35)25(18-21-10-8-7-9-11-21)31-27(34)24(17-20(2)3)30-26(33)19-22-12-14-23(29)15-13-22/h12-15,20-21,24-25H,5-11,16-19H2,1-4H3,(H,30,33)(H,31,34)/t24-,25-/m0/s1
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 36n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of gamma-secretase activity in H4 human neuroglioma cells by measuring amyloid beta production

Bioorg Med Chem Lett 14: 1917-21 (2004)


BindingDB Entry DOI: 10.7270/Q2TT4T4K
More data for this
Ligand-Target Pair