null
SMILES: COC(=O)c1ccccc1NCC1=NCCN1
InChI Key: InChIKey=CGAOZWXESGMCAM-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alpha-1B adrenergic receptor (Homo sapiens (Human)) | BDBM50219153 (CHEMBL414185) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.398 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of DiTc binding to Kv1.3 channel in human brain membranes | Bioorg Med Chem Lett 13: 1183-6 (2003) BindingDB Entry DOI: 10.7270/Q21V5G8T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1B adrenergic receptor (Homo sapiens (Human)) | BDBM50219153 (CHEMBL414185) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.398 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts. | Bioorg Med Chem Lett 11: 2871-4 (2001) BindingDB Entry DOI: 10.7270/Q2CC1201 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1B adrenergic receptor (Homo sapiens (Human)) | BDBM50219153 (CHEMBL414185) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.398 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function... | Bioorg Med Chem Lett 12: 575-9 (2002) BindingDB Entry DOI: 10.7270/Q2Z320ZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1D adrenergic receptor (Homo sapiens (Human)) | BDBM50219153 (CHEMBL414185) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.501 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as fu... | Bioorg Med Chem Lett 12: 575-9 (2002) BindingDB Entry DOI: 10.7270/Q2Z320ZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1D adrenergic receptor (Homo sapiens (Human)) | BDBM50219153 (CHEMBL414185) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.501 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Effective concentration showing agonistic activity towards Human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells was determined | Bioorg Med Chem Lett 13: 1183-6 (2003) BindingDB Entry DOI: 10.7270/Q21V5G8T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1D adrenergic receptor (Homo sapiens (Human)) | BDBM50219153 (CHEMBL414185) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.501 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts. | Bioorg Med Chem Lett 11: 2871-4 (2001) BindingDB Entry DOI: 10.7270/Q2CC1201 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50219153 (CHEMBL414185) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.794 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts. | Bioorg Med Chem Lett 11: 2871-4 (2001) BindingDB Entry DOI: 10.7270/Q2CC1201 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50219153 (CHEMBL414185) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.794 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Effective concentration showing agonistic activity towards Human alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cells was determined | Bioorg Med Chem Lett 13: 1183-6 (2003) BindingDB Entry DOI: 10.7270/Q21V5G8T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50219153 (CHEMBL414185) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.794 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function... | Bioorg Med Chem Lett 12: 575-9 (2002) BindingDB Entry DOI: 10.7270/Q2Z320ZN | |||||||||||
More data for this Ligand-Target Pair |