BDBM50219269 (5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)quinolin-5-yl)oxazol-4-yl)(4-(4,6-dimethoxypyrimidin-2-yl)piperazin-1-yl)methanone::CHEMBL401345

SMILES: COc1cc(OC)nc(n1)N1CCN(CC1)C(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F

InChI Key: InChIKey=JQWUZRQDRJVXDJ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50219269   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 11A (Homo sapiens (Human))	BDBM50219269 ((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...) Show SMILES COc1cc(OC)nc(n1)N1CCN(CC1)C(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F Show InChI InChI=1S/C26H26F3N7O5/c1-38-16-6-4-15(14-5-7-18(26(27,28)29)31-21(14)16)23-34-22(17(13-30)41-23)24(37)35-8-10-36(11-9-35)25-32-19(39-2)12-20(33-25)40-3/h4-7,12H,8-11,13,30H2,1-3H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE11				Bioorg Med Chem Lett 17: 5150-4 (2007) Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50219269 ((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...) Show SMILES COc1cc(OC)nc(n1)N1CCN(CC1)C(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F Show InChI InChI=1S/C26H26F3N7O5/c1-38-16-6-4-15(14-5-7-18(26(27,28)29)31-21(14)16)23-34-22(17(13-30)41-23)24(37)35-8-10-36(11-9-35)25-32-19(39-2)12-20(33-25)40-3/h4-7,12H,8-11,13,30H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	760	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE10				Bioorg Med Chem Lett 17: 5150-4 (2007) Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50219269 ((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...) Show SMILES COc1cc(OC)nc(n1)N1CCN(CC1)C(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F Show InChI InChI=1S/C26H26F3N7O5/c1-38-16-6-4-15(14-5-7-18(26(27,28)29)31-21(14)16)23-34-22(17(13-30)41-23)24(37)35-8-10-36(11-9-35)25-32-19(39-2)12-20(33-25)40-3/h4-7,12H,8-11,13,30H2,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE4B				Bioorg Med Chem Lett 17: 5150-4 (2007) Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H
					More data for this Ligand-Target Pair