BDBM50220589 6-(1-hydroxy-2-(4-hydroxy-4-(3-(phenoxymethyl)phenyl)piperidin-1-yl)propyl)-3,4-dihydroquinolin-2(1H)-one::CHEMBL247841

SMILES: CC(C(O)c1ccc2NC(=O)CCc2c1)N1CCC(O)(CC1)c1cccc(COc2ccccc2)c1

InChI Key: InChIKey=PYYPZMAUJKZZBD-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50220589   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50220589 (6-(1-hydroxy-2-(4-hydroxy-4-(3-(phenoxymethyl)phen...) Show SMILES CC(C(O)c1ccc2NC(=O)CCc2c1)N1CCC(O)(CC1)c1cccc(COc2ccccc2)c1 |w:2.2,1.0| Show InChI InChI=1S/C30H34N2O4/c1-21(29(34)24-10-12-27-23(19-24)11-13-28(33)31-27)32-16-14-30(35,15-17-32)25-7-5-6-22(18-25)20-36-26-8-3-2-4-9-26/h2-10,12,18-19,21,29,34-35H,11,13-17,20H2,1H3,(H,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane				Bioorg Med Chem Lett 17: 5558-62 (2007) Article DOI: 10.1016/j.bmcl.2007.08.014 BindingDB Entry DOI: 10.7270/Q2R21138
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