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BDBM50220720 CHEMBL237752::N-((1s,4s)-4-hydroxy-4-(2-oxo-2,3-dihydrooxazolo[4,5-b]pyridin-6-yl)cyclohexyl)-3-phenylpropanamide

SMILES: O[C@@]1(CC[C@@H](CC1)NC(=O)CCc1ccccc1)c1c[nH]c2nc(=O)oc2c1

InChI Key: InChIKey=SKJPTQRULJBLIZ-NBEIKUQISA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50220720   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))		BDBM50220720
PNG
(CHEMBL237752 | N-((1s,4s)-4-hydroxy-4-(2-oxo-2,3-d...)
Show SMILES O[C@@]1(CC[C@@H](CC1)NC(=O)CCc1ccccc1)c1c[nH]c2nc(=O)oc2c1 |wD:1.0,4.7,(16.47,-54.83,;16.48,-53.3,;16.48,-51.76,;17.81,-50.98,;19.14,-51.76,;19.14,-53.3,;17.81,-54.07,;20.48,-51,;21.81,-51.77,;21.81,-53.31,;23.16,-51.01,;24.48,-51.79,;25.81,-51.02,;27.13,-51.8,;28.47,-51.05,;28.49,-49.51,;27.17,-48.73,;25.83,-49.48,;15.14,-54.08,;15.16,-55.61,;13.83,-56.39,;12.47,-55.63,;11.01,-56.1,;10.1,-54.85,;8.55,-54.85,;11.01,-53.6,;12.48,-54.08,;13.81,-53.31,)|
Show InChI InChI=1S/C21H23N3O4/c25-18(7-6-14-4-2-1-3-5-14)23-16-8-10-21(27,11-9-16)15-12-17-19(22-13-15)24-20(26)28-17/h1-5,12-13,16,27H,6-11H2,(H,23,25)(H,22,24,26)/t16-,21+
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 85n/an/an/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Displacement of [3H]CP101,606 from NR2B in rat forebrain P2 membrane

Bioorg Med Chem Lett 17: 5533-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.039
BindingDB Entry DOI: 10.7270/Q23778FR
More data for this
Ligand-Target Pair