BDBM50221533 4-((1R,2S)-2-(3-bromophenyl)cyclopropylamino)-6,7-dimethoxyquinoline-3-carbonitrile::CHEMBL248425
SMILES: COc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3cccc(Br)c3)c2cc1OC
InChI Key: InChIKey=VEKGKQDLGQZPEO-MAUKXSAKSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50221533 (4-((1R,2S)-2-(3-bromophenyl)cyclopropylamino)-6,7-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant EGFR by fluorescence polarization assay | Bioorg Med Chem Lett 17: 5978-82 (2007) Article DOI: 10.1016/j.bmcl.2007.07.071 BindingDB Entry DOI: 10.7270/Q2VM4C0N | |||||||||||
More data for this Ligand-Target Pair |