BDBM50222360 Ac-Asp-Arg-Leu-Asp-Ser-OH::CHEMBL238484
SMILES: [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](-[#6])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](-[#8])=O
InChI Key: InChIKey=MBZXDXZGPJKBRJ-WOYTXXSLSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ITGAV/ITGB3 (Homo sapiens (Human)) | BDBM50222360 (Ac-Asp-Arg-Leu-Asp-Ser-OH | CHEMBL238484) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bologna Curated by ChEMBL | Assay Description Antagonist activity at alphavbeta3 integrin in human SK-MEL-24 cells assessed as inhibition of fibronectin-mediated cell adhesion after 30 mins by fl... | Eur J Med Chem 83: 284-93 (2014) Article DOI: 10.1016/j.ejmech.2014.06.041 BindingDB Entry DOI: 10.7270/Q2S75HWX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ITGA5/ITGB1 (Homo sapiens (Human)) | BDBM50222360 (Ac-Asp-Arg-Leu-Asp-Ser-OH | CHEMBL238484) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.59E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Bologna Curated by ChEMBL | Assay Description Inhibition of integrin alpha5beta1-mediated K562 cell adhesion to fibronectin | Bioorg Med Chem 15: 7380-90 (2007) Article DOI: 10.1016/j.bmc.2007.07.049 BindingDB Entry DOI: 10.7270/Q2N0167H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ITGAV/ITGB3 (Homo sapiens (Human)) | BDBM50222360 (Ac-Asp-Arg-Leu-Asp-Ser-OH | CHEMBL238484) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Bologna Curated by ChEMBL | Assay Description Inhibition of integrin alphavbeta3-mediated SK-MEL-24 cell adhesion to fibronectin | Bioorg Med Chem 15: 7380-90 (2007) Article DOI: 10.1016/j.bmc.2007.07.049 BindingDB Entry DOI: 10.7270/Q2N0167H | |||||||||||
More data for this Ligand-Target Pair |