BDBM50223028 CHEMBL250616::N2-(3,5-dichloropyridin-2-yl)-3,6-diethyl-N5-(pentan-3-yl)pyrazine-2,5-diamine

SMILES: CCC(CC)Nc1nc(CC)c(Nc2ncc(Cl)cc2Cl)nc1CC

InChI Key: InChIKey=SPZYMZVLPWCGQG-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50223028   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50223028 (CHEMBL250616 | N2-(3,5-dichloropyridin-2-yl)-3,6-d...) Show SMILES CCC(CC)Nc1nc(CC)c(Nc2ncc(Cl)cc2Cl)nc1CC Show InChI InChI=1S/C18H25Cl2N5/c1-5-12(6-2)22-17-14(7-3)24-18(15(8-4)23-17)25-16-13(20)9-11(19)10-21-16/h9-10,12H,5-8H2,1-4H3,(H,22,23)(H,21,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	115	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]Tyr-o-CRF from CRF1 receptor in IMR32 cells				Bioorg Med Chem Lett 17: 6250-6 (2007) Article DOI: 10.1016/j.bmcl.2007.09.008 BindingDB Entry DOI: 10.7270/Q2F76C8G
					More data for this Ligand-Target Pair