BDBM50223162 CHEMBL31743

SMILES: CCCCc1nc(N2CCc3ccccc3C2)c2sccc2n1

InChI Key: InChIKey=JYLSTYNCFFFRAP-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50223162   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50223162 (CHEMBL31743) Show SMILES CCCCc1nc(N2CCc3ccccc3C2)c2sccc2n1 Show InChI InChI=1S/C19H21N3S/c1-2-3-8-17-20-16-10-12-23-18(16)19(21-17)22-11-9-14-6-4-5-7-15(14)13-22/h4-7,10,12H,2-3,8-9,11,13H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research (NIPER) Curated by ChEMBL					Assay Description Inhibitory activity against (PDE IV) phosphodiesterase IV in guinea pig articular tissue				Bioorg Med Chem Lett 13: 1403-8 (2003) BindingDB Entry DOI: 10.7270/Q29025ZS
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50223162 (CHEMBL31743) Show SMILES CCCCc1nc(N2CCc3ccccc3C2)c2sccc2n1 Show InChI InChI=1S/C19H21N3S/c1-2-3-8-17-20-16-10-12-23-18(16)19(21-17)22-11-9-14-6-4-5-7-15(14)13-22/h4-7,10,12H,2-3,8-9,11,13H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase 4 isolated from guinea pig ventricular tissue				J Med Chem 41: 4021-35 (1998) Article DOI: 10.1021/jm981012m BindingDB Entry DOI: 10.7270/Q2TM7DV3
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus)	BDBM50223162 (CHEMBL31743) Show SMILES CCCCc1nc(N2CCc3ccccc3C2)c2sccc2n1 Show InChI InChI=1S/C19H21N3S/c1-2-3-8-17-20-16-10-12-23-18(16)19(21-17)22-11-9-14-6-4-5-7-15(14)13-22/h4-7,10,12H,2-3,8-9,11,13H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Affinity for the high affinity rolipram binding site of phosphodiesterase (PDE IV) by [3H]rolipram displacement.				J Med Chem 41: 4021-35 (1998) Article DOI: 10.1021/jm981012m BindingDB Entry DOI: 10.7270/Q2TM7DV3
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50223162 (CHEMBL31743) Show SMILES CCCCc1nc(N2CCc3ccccc3C2)c2sccc2n1 Show InChI InChI=1S/C19H21N3S/c1-2-3-8-17-20-16-10-12-23-18(16)19(21-17)22-11-9-14-6-4-5-7-15(14)13-22/h4-7,10,12H,2-3,8-9,11,13H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory activity against cGMP inhibited Phosphodiesterase 3, isolated from guinea pig ventricular tissue				J Med Chem 41: 4021-35 (1998) Article DOI: 10.1021/jm981012m BindingDB Entry DOI: 10.7270/Q2TM7DV3
					More data for this Ligand-Target Pair