BDBM50224025 6-(4-(2-((S)-2-hydroxy-3-(3-methyl-2-oxoindolin-4-yloxy)propylamino)-2-methylpropyl)phenoxy)nicotinamide::CHEMBL404626

SMILES: CC1C(=O)Nc2cccc(OC[C@@H](O)CNC(C)(C)Cc3ccc(Oc4ccc(cn4)C(N)=O)cc3)c12

InChI Key: InChIKey=WAMWYZOEWMINIF-OZBJMMHXSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50224025   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-2 adrenergic receptor (Homo sapiens (Human))	BDBM50224025 (6-(4-(2-((S)-2-hydroxy-3-(3-methyl-2-oxoindolin-4-...) Show SMILES CC1C(=O)Nc2cccc(OC[C@@H](O)CNC(C)(C)Cc3ccc(Oc4ccc(cn4)C(N)=O)cc3)c12 |w:1.0| Show InChI InChI=1S/C28H32N4O5/c1-17-25-22(32-27(17)35)5-4-6-23(25)36-16-20(33)15-31-28(2,3)13-18-7-10-21(11-8-18)37-24-12-9-19(14-30-24)26(29)34/h4-12,14,17,20,31,33H,13,15-16H2,1-3H3,(H2,29,34)(H,32,35)/t17?,20-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP level				Bioorg Med Chem Lett 17: 6270-3 (2007) Article DOI: 10.1016/j.bmcl.2007.09.011 BindingDB Entry DOI: 10.7270/Q22V2FV6
					More data for this Ligand-Target Pair
Beta-1 adrenergic receptor (Homo sapiens (Human))	BDBM50224025 (6-(4-(2-((S)-2-hydroxy-3-(3-methyl-2-oxoindolin-4-...) Show SMILES CC1C(=O)Nc2cccc(OC[C@@H](O)CNC(C)(C)Cc3ccc(Oc4ccc(cn4)C(N)=O)cc3)c12 |w:1.0| Show InChI InChI=1S/C28H32N4O5/c1-17-25-22(32-27(17)35)5-4-6-23(25)36-16-20(33)15-31-28(2,3)13-18-7-10-21(11-8-18)37-24-12-9-19(14-30-24)26(29)34/h4-12,14,17,20,31,33H,13,15-16H2,1-3H3,(H2,29,34)(H,32,35)/t17?,20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP level				Bioorg Med Chem Lett 17: 6270-3 (2007) Article DOI: 10.1016/j.bmcl.2007.09.011 BindingDB Entry DOI: 10.7270/Q22V2FV6
					More data for this Ligand-Target Pair
Beta-3 adrenergic receptor (Homo sapiens (Human))	BDBM50224025 (6-(4-(2-((S)-2-hydroxy-3-(3-methyl-2-oxoindolin-4-...) Show SMILES CC1C(=O)Nc2cccc(OC[C@@H](O)CNC(C)(C)Cc3ccc(Oc4ccc(cn4)C(N)=O)cc3)c12 |w:1.0| Show InChI InChI=1S/C28H32N4O5/c1-17-25-22(32-27(17)35)5-4-6-23(25)36-16-20(33)15-31-28(2,3)13-18-7-10-21(11-8-18)37-24-12-9-19(14-30-24)26(29)34/h4-12,14,17,20,31,33H,13,15-16H2,1-3H3,(H2,29,34)(H,32,35)/t17?,20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP level				Bioorg Med Chem Lett 17: 6270-3 (2007) Article DOI: 10.1016/j.bmcl.2007.09.011 BindingDB Entry DOI: 10.7270/Q22V2FV6
					More data for this Ligand-Target Pair