null

SMILES: C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1cn(C)nc1C

InChI Key: InChIKey=GGGPOYPNHTZKFQ-OAHLLOKOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50224190   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50224190 ((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...) Show SMILES C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1cn(C)nc1C Show InChI InChI=1S/C21H26N4/c1-15-5-4-11-25(15)12-10-17-6-8-20-18(13-17)7-9-21(22-20)19-14-24(3)23-16(19)2/h6-9,13-15H,4-5,10-12H2,1-3H3/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptor				Bioorg Med Chem Lett 20: 3295-300 (2010) Article DOI: 10.1016/j.bmcl.2010.04.045 BindingDB Entry DOI: 10.7270/Q2XW4JZN
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50224190 ((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...) Show SMILES C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1cn(C)nc1C Show InChI InChI=1S/C21H26N4/c1-15-5-4-11-25(15)12-10-17-6-8-20-18(13-17)7-9-21(22-20)19-14-24(3)23-16(19)2/h6-9,13-15H,4-5,10-12H2,1-3H3/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha methyl histamine from human H3 receptor expressed in C6 cells				J Med Chem 50: 5439-48 (2007) Article DOI: 10.1021/jm0705051 BindingDB Entry DOI: 10.7270/Q25M65G0
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50224190 ((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...) Show SMILES C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1cn(C)nc1C Show InChI InChI=1S/C21H26N4/c1-15-5-4-11-25(15)12-10-17-6-8-20-18(13-17)7-9-21(22-20)19-14-24(3)23-16(19)2/h6-9,13-15H,4-5,10-12H2,1-3H3/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bioprojet-Biotech Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assay				Bioorg Med Chem Lett 21: 5378-83 (2011) Article DOI: 10.1016/j.bmcl.2011.07.006 BindingDB Entry DOI: 10.7270/Q2VX0GXK
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50224190 ((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...) Show SMILES C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1cn(C)nc1C Show InChI InChI=1S/C21H26N4/c1-15-5-4-11-25(15)12-10-17-6-8-20-18(13-17)7-9-21(22-20)19-14-24(3)23-16(19)2/h6-9,13-15H,4-5,10-12H2,1-3H3/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from rat cloned histamine H3 receptor				Bioorg Med Chem Lett 20: 3295-300 (2010) Article DOI: 10.1016/j.bmcl.2010.04.045 BindingDB Entry DOI: 10.7270/Q2XW4JZN
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50224190 ((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...) Show SMILES C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1cn(C)nc1C Show InChI InChI=1S/C21H26N4/c1-15-5-4-11-25(15)12-10-17-6-8-20-18(13-17)7-9-21(22-20)19-14-24(3)23-16(19)2/h6-9,13-15H,4-5,10-12H2,1-3H3/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.62	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha methyl histamine from rat H3 receptor expressed in C6 cells				J Med Chem 50: 5439-48 (2007) Article DOI: 10.1021/jm0705051 BindingDB Entry DOI: 10.7270/Q25M65G0
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50224190 ((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...) Show SMILES C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1cn(C)nc1C Show InChI InChI=1S/C21H26N4/c1-15-5-4-11-25(15)12-10-17-6-8-20-18(13-17)7-9-21(22-20)19-14-24(3)23-16(19)2/h6-9,13-15H,4-5,10-12H2,1-3H3/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.09	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as inhibition of RAMH-stimulated [35S]GTPgammaS binding				J Med Chem 50: 5439-48 (2007) Article DOI: 10.1021/jm0705051 BindingDB Entry DOI: 10.7270/Q25M65G0
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50224190 ((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...) Show SMILES C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1cn(C)nc1C Show InChI InChI=1S/C21H26N4/c1-15-5-4-11-25(15)12-10-17-6-8-20-18(13-17)7-9-21(22-20)19-14-24(3)23-16(19)2/h6-9,13-15H,4-5,10-12H2,1-3H3/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells				Bioorg Med Chem Lett 20: 3295-300 (2010) Article DOI: 10.1016/j.bmcl.2010.04.045 BindingDB Entry DOI: 10.7270/Q2XW4JZN
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50224190 ((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...) Show SMILES C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1cn(C)nc1C Show InChI InChI=1S/C21H26N4/c1-15-5-4-11-25(15)12-10-17-6-8-20-18(13-17)7-9-21(22-20)19-14-24(3)23-16(19)2/h6-9,13-15H,4-5,10-12H2,1-3H3/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Agonist activity at human histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS binding				J Med Chem 50: 5439-48 (2007) Article DOI: 10.1021/jm0705051 BindingDB Entry DOI: 10.7270/Q25M65G0
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50224190 ((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...) Show SMILES C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1cn(C)nc1C Show InChI InChI=1S/C21H26N4/c1-15-5-4-11-25(15)12-10-17-6-8-20-18(13-17)7-9-21(22-20)19-14-24(3)23-16(19)2/h6-9,13-15H,4-5,10-12H2,1-3H3/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.48E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bioprojet-Biotech Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay				Bioorg Med Chem Lett 21: 5378-83 (2011) Article DOI: 10.1016/j.bmcl.2011.07.006 BindingDB Entry DOI: 10.7270/Q2VX0GXK
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50224190 ((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...) Show SMILES C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1cn(C)nc1C Show InChI InChI=1S/C21H26N4/c1-15-5-4-11-25(15)12-10-17-6-8-20-18(13-17)7-9-21(22-20)19-14-24(3)23-16(19)2/h6-9,13-15H,4-5,10-12H2,1-3H3/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.75	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Agonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS binding				J Med Chem 50: 5439-48 (2007) Article DOI: 10.1021/jm0705051 BindingDB Entry DOI: 10.7270/Q25M65G0
					More data for this Ligand-Target Pair