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BDBM50225005 2-(4-((1s,4s)-4-(hydroxymethyl)cyclohexyloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide::CHEMBL249570

SMILES: NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(O[C@@H]2CC[C@H](CO)CC2)cc1

InChI Key: InChIKey=PKRGVSAGNQDZDA-AKAXFMLLSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50225005   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase CHK2


(Homo sapiens (Human))
BDBM50225005
PNG
(2-(4-((1s,4s)-4-(hydroxymethyl)cyclohexyloxy)pheny...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(O[C@@H]2CC[C@H](CO)CC2)cc1 |wU:17.18,20.22,(-8.66,-18.67,;-7.34,-17.9,;-7.34,-16.37,;-5.99,-18.68,;-5.99,-20.21,;-4.65,-20.98,;-3.33,-20.21,;-1.87,-20.69,;-.97,-19.45,;-1.87,-18.2,;-3.33,-18.67,;-4.65,-17.91,;.57,-19.53,;1.3,-20.9,;2.84,-20.96,;3.67,-19.64,;5.2,-19.69,;6,-18.37,;7.55,-18.41,;8.33,-17.09,;7.61,-15.73,;8.42,-14.42,;9.95,-14.47,;6.06,-15.69,;5.26,-17.01,;2.95,-18.3,;1.4,-18.24,)|
Show InChI InChI=1S/C21H23N3O3/c22-20(26)15-5-10-18-19(11-15)24-21(23-18)14-3-8-17(9-4-14)27-16-6-1-13(12-25)2-7-16/h3-5,8-11,13,16,25H,1-2,6-7,12H2,(H2,22,26)(H,23,24)/t13-,16+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Chk2


Bioorg Med Chem Lett 17: 6467-71 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.098
BindingDB Entry DOI: 10.7270/Q2KP81XB
More data for this
Ligand-Target Pair