BDBM50225227 2,4-dichloro-1-(4-(chloromethyl)-2-methoxyphenoxy)benzene::CHEMBL240807
SMILES: COc1cc(CCl)ccc1Oc1ccc(Cl)cc1Cl
InChI Key: InChIKey=KGFZDWAEBKKPMK-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transthyretin (Homo sapiens (Human)) | BDBM50225227 (2,4-dichloro-1-(4-(chloromethyl)-2-methoxyphenoxy)...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Institute of Sciences Curated by ChEMBL | Assay Description Inhibition of transthyretin fibril formation at pH 4.4 | J Med Chem 50: 5589-99 (2007) Article DOI: 10.1021/jm0700159 BindingDB Entry DOI: 10.7270/Q2PG1RGD | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |