BDBM50227099 2-(1-(4-amino-3,5-diethoxybenzyl)piperidin-4-ylamino)benzo[d]oxazole-5-sulfonamide::CHEMBL236788
SMILES: CCOc1cc(CN2CCC(CC2)Nc2nc3cc(ccc3o2)S(N)(=O)=O)cc(OCC)c1N
InChI Key: InChIKey=OFGZKSUTEKHHAS-UHFFFAOYSA-N
Data: 12 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM50227099 (2-(1-(4-amino-3,5-diethoxybenzyl)piperidin-4-ylami...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of SST14 from human recombinant SST5 receptor expressed in CHO cells by radioligand binding assay | Bioorg Med Chem Lett 19: 6106-13 (2009) Article DOI: 10.1016/j.bmcl.2009.09.024 BindingDB Entry DOI: 10.7270/Q2PC32H9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM50227099 (2-(1-(4-amino-3,5-diethoxybenzyl)piperidin-4-ylami...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel Curated by ChEMBL | Assay Description Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombinant sst5 receptor expressed in chinese hamster CCL39 cells | J Med Chem 52: 95-104 (2009) Article DOI: 10.1021/jm801205x BindingDB Entry DOI: 10.7270/Q27W6D3B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM50227099 (2-(1-(4-amino-3,5-diethoxybenzyl)piperidin-4-ylami...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Displacement of [125I]11-Tyr somatostatin-14 from human SST5R expressed in CHO cells | J Med Chem 50: 6291-4 (2007) Article DOI: 10.1021/jm701143p BindingDB Entry DOI: 10.7270/Q2WS8T0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 1 (Homo sapiens (Human)) | BDBM50227099 (2-(1-(4-amino-3,5-diethoxybenzyl)piperidin-4-ylami...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of SST14 from human recombinant SST1 receptor | Bioorg Med Chem Lett 19: 6106-13 (2009) Article DOI: 10.1016/j.bmcl.2009.09.024 BindingDB Entry DOI: 10.7270/Q2PC32H9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (Homo sapiens (Human)) | BDBM50227099 (2-(1-(4-amino-3,5-diethoxybenzyl)piperidin-4-ylami...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Binding affinity to human histamine H1 receptor | Bioorg Med Chem Lett 19: 6106-13 (2009) Article DOI: 10.1016/j.bmcl.2009.09.024 BindingDB Entry DOI: 10.7270/Q2PC32H9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 1 (Homo sapiens (Human)) | BDBM50227099 (2-(1-(4-amino-3,5-diethoxybenzyl)piperidin-4-ylami...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Binding affinity to human SST1R | J Med Chem 50: 6291-4 (2007) Article DOI: 10.1021/jm701143p BindingDB Entry DOI: 10.7270/Q2WS8T0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 3 (Homo sapiens (Human)) | BDBM50227099 (2-(1-(4-amino-3,5-diethoxybenzyl)piperidin-4-ylami...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of SST14 from human recombinant SST3 receptor | Bioorg Med Chem Lett 19: 6106-13 (2009) Article DOI: 10.1016/j.bmcl.2009.09.024 BindingDB Entry DOI: 10.7270/Q2PC32H9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM50227099 (2-(1-(4-amino-3,5-diethoxybenzyl)piperidin-4-ylami...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of SST14 from human recombinant SST4 receptor | Bioorg Med Chem Lett 19: 6106-13 (2009) Article DOI: 10.1016/j.bmcl.2009.09.024 BindingDB Entry DOI: 10.7270/Q2PC32H9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM50227099 (2-(1-(4-amino-3,5-diethoxybenzyl)piperidin-4-ylami...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Binding affinity to human SST4R | J Med Chem 50: 6291-4 (2007) Article DOI: 10.1021/jm701143p BindingDB Entry DOI: 10.7270/Q2WS8T0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 2 (Homo sapiens (Human)) | BDBM50227099 (2-(1-(4-amino-3,5-diethoxybenzyl)piperidin-4-ylami...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Binding affinity to human SST2R | J Med Chem 50: 6291-4 (2007) Article DOI: 10.1021/jm701143p BindingDB Entry DOI: 10.7270/Q2WS8T0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 3 (Homo sapiens (Human)) | BDBM50227099 (2-(1-(4-amino-3,5-diethoxybenzyl)piperidin-4-ylami...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Binding affinity to human SST3R | J Med Chem 50: 6291-4 (2007) Article DOI: 10.1021/jm701143p BindingDB Entry DOI: 10.7270/Q2WS8T0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 2 (Homo sapiens (Human)) | BDBM50227099 (2-(1-(4-amino-3,5-diethoxybenzyl)piperidin-4-ylami...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of SST14 from human recombinant SST2 receptor | Bioorg Med Chem Lett 19: 6106-13 (2009) Article DOI: 10.1016/j.bmcl.2009.09.024 BindingDB Entry DOI: 10.7270/Q2PC32H9 | |||||||||||
More data for this Ligand-Target Pair |