Found 6 hits for monomerid = 50227996 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50227996
((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro...)Show SMILES CC(C)COC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(C=C1)c1ccccc1)C(=O)NO |w:20.25,c:23| Show InChI InChI=1S/C25H33N3O5/c1-17(2)15-33-24(31)28-16-25(10-11-25)14-20(22(29)26-32)21(28)23(30)27-12-8-19(9-13-27)18-6-4-3-5-7-18/h3-8,12,17,19-21,32H,9-11,13-16H2,1-2H3,(H,26,29)/t19?,20-,21-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 451 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Binding affinity to MMP9 |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
(Homo sapiens (Human)) | BDBM50227996
((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro...)Show SMILES CC(C)COC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(C=C1)c1ccccc1)C(=O)NO |w:20.25,c:23| Show InChI InChI=1S/C25H33N3O5/c1-17(2)15-33-24(31)28-16-25(10-11-25)14-20(22(29)26-32)21(28)23(30)27-12-8-19(9-13-27)18-6-4-3-5-7-18/h3-8,12,17,19-21,32H,9-11,13-16H2,1-2H3,(H,26,29)/t19?,20-,21-/m0/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assay |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50227996
((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro...)Show SMILES CC(C)COC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(C=C1)c1ccccc1)C(=O)NO |w:20.25,c:23| Show InChI InChI=1S/C25H33N3O5/c1-17(2)15-33-24(31)28-16-25(10-11-25)14-20(22(29)26-32)21(28)23(30)27-12-8-19(9-13-27)18-6-4-3-5-7-18/h3-8,12,17,19-21,32H,9-11,13-16H2,1-2H3,(H,26,29)/t19?,20-,21-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Binding affinity to MMP2 |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
(Homo sapiens (Human)) | BDBM50227996
((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro...)Show SMILES CC(C)COC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(C=C1)c1ccccc1)C(=O)NO |w:20.25,c:23| Show InChI InChI=1S/C25H33N3O5/c1-17(2)15-33-24(31)28-16-25(10-11-25)14-20(22(29)26-32)21(28)23(30)27-12-8-19(9-13-27)18-6-4-3-5-7-18/h3-8,12,17,19-21,32H,9-11,13-16H2,1-2H3,(H,26,29)/t19?,20-,21-/m0/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assay |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50227996
((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro...)Show SMILES CC(C)COC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(C=C1)c1ccccc1)C(=O)NO |w:20.25,c:23| Show InChI InChI=1S/C25H33N3O5/c1-17(2)15-33-24(31)28-16-25(10-11-25)14-20(22(29)26-32)21(28)23(30)27-12-8-19(9-13-27)18-6-4-3-5-7-18/h3-8,12,17,19-21,32H,9-11,13-16H2,1-2H3,(H,26,29)/t19?,20-,21-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Binding affinity to MMP3 |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |
Interstitial collagenase
(Homo sapiens (Human)) | BDBM50227996
((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro...)Show SMILES CC(C)COC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(C=C1)c1ccccc1)C(=O)NO |w:20.25,c:23| Show InChI InChI=1S/C25H33N3O5/c1-17(2)15-33-24(31)28-16-25(10-11-25)14-20(22(29)26-32)21(28)23(30)27-12-8-19(9-13-27)18-6-4-3-5-7-18/h3-8,12,17,19-21,32H,9-11,13-16H2,1-2H3,(H,26,29)/t19?,20-,21-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Binding affinity to MMP1 |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |