Found 6 hits for monomerid = 50227998 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
(Homo sapiens (Human)) | BDBM50227998
((6S,7S)-5-acetyl-6-(4-phenyl-3,4-dihydro-2H-pyridi...)Show SMILES CC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(C=C1)c1ccccc1)C(=O)NO |w:16.21,c:19| Show InChI InChI=1S/C22H27N3O4/c1-15(26)25-14-22(9-10-22)13-18(20(27)23-29)19(25)21(28)24-11-7-17(8-12-24)16-5-3-2-4-6-16/h2-7,11,17-19,29H,8-10,12-14H2,1H3,(H,23,27)/t17?,18-,19-/m0/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Binding affinity to ADAM10 |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50227998
((6S,7S)-5-acetyl-6-(4-phenyl-3,4-dihydro-2H-pyridi...)Show SMILES CC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(C=C1)c1ccccc1)C(=O)NO |w:16.21,c:19| Show InChI InChI=1S/C22H27N3O4/c1-15(26)25-14-22(9-10-22)13-18(20(27)23-29)19(25)21(28)24-11-7-17(8-12-24)16-5-3-2-4-6-16/h2-7,11,17-19,29H,8-10,12-14H2,1H3,(H,23,27)/t17?,18-,19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Binding affinity to MMP9 |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50227998
((6S,7S)-5-acetyl-6-(4-phenyl-3,4-dihydro-2H-pyridi...)Show SMILES CC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(C=C1)c1ccccc1)C(=O)NO |w:16.21,c:19| Show InChI InChI=1S/C22H27N3O4/c1-15(26)25-14-22(9-10-22)13-18(20(27)23-29)19(25)21(28)24-11-7-17(8-12-24)16-5-3-2-4-6-16/h2-7,11,17-19,29H,8-10,12-14H2,1H3,(H,23,27)/t17?,18-,19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Binding affinity to MMP3 |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |
Interstitial collagenase
(Homo sapiens (Human)) | BDBM50227998
((6S,7S)-5-acetyl-6-(4-phenyl-3,4-dihydro-2H-pyridi...)Show SMILES CC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(C=C1)c1ccccc1)C(=O)NO |w:16.21,c:19| Show InChI InChI=1S/C22H27N3O4/c1-15(26)25-14-22(9-10-22)13-18(20(27)23-29)19(25)21(28)24-11-7-17(8-12-24)16-5-3-2-4-6-16/h2-7,11,17-19,29H,8-10,12-14H2,1H3,(H,23,27)/t17?,18-,19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Binding affinity to MMP1 |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50227998
((6S,7S)-5-acetyl-6-(4-phenyl-3,4-dihydro-2H-pyridi...)Show SMILES CC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(C=C1)c1ccccc1)C(=O)NO |w:16.21,c:19| Show InChI InChI=1S/C22H27N3O4/c1-15(26)25-14-22(9-10-22)13-18(20(27)23-29)19(25)21(28)24-11-7-17(8-12-24)16-5-3-2-4-6-16/h2-7,11,17-19,29H,8-10,12-14H2,1H3,(H,23,27)/t17?,18-,19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Binding affinity to MMP2 |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
(Homo sapiens (Human)) | BDBM50227998
((6S,7S)-5-acetyl-6-(4-phenyl-3,4-dihydro-2H-pyridi...)Show SMILES CC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(C=C1)c1ccccc1)C(=O)NO |w:16.21,c:19| Show InChI InChI=1S/C22H27N3O4/c1-15(26)25-14-22(9-10-22)13-18(20(27)23-29)19(25)21(28)24-11-7-17(8-12-24)16-5-3-2-4-6-16/h2-7,11,17-19,29H,8-10,12-14H2,1H3,(H,23,27)/t17?,18-,19-/m0/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assay |
Bioorg Med Chem Lett 18: 159-63 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.108 BindingDB Entry DOI: 10.7270/Q2GM8720 |
More data for this Ligand-Target Pair | |