BDBM50229092 1-(4-(3-(2-(6-methylpyridin-2-ylamino)thiazol-5-ylthio)benzoyl)piperazin-1-yl)ethanone::CHEMBL438697

SMILES: CC(=O)N1CCN(CC1)C(=O)c1cccc(Sc2cnc(Nc3cccc(C)n3)s2)c1

InChI Key: InChIKey=BYWPWIAXEQRKNW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50229092   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50229092 (1-(4-(3-(2-(6-methylpyridin-2-ylamino)thiazol-5-yl...) Show SMILES CC(=O)N1CCN(CC1)C(=O)c1cccc(Sc2cnc(Nc3cccc(C)n3)s2)c1 Show InChI InChI=1S/C22H23N5O2S2/c1-15-5-3-8-19(24-15)25-22-23-14-20(31-22)30-18-7-4-6-17(13-18)21(29)27-11-9-26(10-12-27)16(2)28/h3-8,13-14H,9-12H2,1-2H3,(H,23,24,25)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of TrkA				Bioorg Med Chem Lett 18: 634-9 (2008) Article DOI: 10.1016/j.bmcl.2007.11.076 BindingDB Entry DOI: 10.7270/Q2JD4WJ5
					More data for this Ligand-Target Pair