BDBM50229094 1-(4-(2-methyl-5-(2-(pyridin-2-ylamino)thiazol-5-ylthio)benzoyl)-1,4-diazepan-1-yl)ethanone::CHEMBL254479

SMILES: CC(=O)N1CCCN(CC1)C(=O)c1cc(Sc2cnc(Nc3ccccn3)s2)ccc1C

InChI Key: InChIKey=GSVDMIHCJGKTJI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50229094   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50229094 (1-(4-(2-methyl-5-(2-(pyridin-2-ylamino)thiazol-5-y...) Show SMILES CC(=O)N1CCCN(CC1)C(=O)c1cc(Sc2cnc(Nc3ccccn3)s2)ccc1C Show InChI InChI=1S/C23H25N5O2S2/c1-16-7-8-18(31-21-15-25-23(32-21)26-20-6-3-4-9-24-20)14-19(16)22(30)28-11-5-10-27(12-13-28)17(2)29/h3-4,6-9,14-15H,5,10-13H2,1-2H3,(H,24,25,26)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of TrkA				Bioorg Med Chem Lett 18: 634-9 (2008) Article DOI: 10.1016/j.bmcl.2007.11.076 BindingDB Entry DOI: 10.7270/Q2JD4WJ5
					More data for this Ligand-Target Pair