Found 4 hits for monomerid = 50229101 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Insulin-like growth factor I receptor
(Homo sapiens (Human)) | BDBM50229101
(5-(2-(6-bromopyridin-2-ylamino)thiazol-5-ylthio)-N...)Show SMILES CNCCN(C)C(=O)c1cc(Sc2cnc(Nc3cccc(Br)n3)s2)ccc1C Show InChI InChI=1S/C20H22BrN5OS2/c1-13-7-8-14(11-15(13)19(27)26(3)10-9-22-2)28-18-12-23-20(29-18)25-17-6-4-5-16(21)24-17/h4-8,11-12,22H,9-10H2,1-3H3,(H,23,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 634-9 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.076 BindingDB Entry DOI: 10.7270/Q2JD4WJ5 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50229101
(5-(2-(6-bromopyridin-2-ylamino)thiazol-5-ylthio)-N...)Show SMILES CNCCN(C)C(=O)c1cc(Sc2cnc(Nc3cccc(Br)n3)s2)ccc1C Show InChI InChI=1S/C20H22BrN5OS2/c1-13-7-8-14(11-15(13)19(27)26(3)10-9-22-2)28-18-12-23-20(29-18)25-17-6-4-5-16(21)24-17/h4-8,11-12,22H,9-10H2,1-3H3,(H,23,24,25) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of TrkA |
Bioorg Med Chem Lett 18: 634-9 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.076 BindingDB Entry DOI: 10.7270/Q2JD4WJ5 |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50229101
(5-(2-(6-bromopyridin-2-ylamino)thiazol-5-ylthio)-N...)Show SMILES CNCCN(C)C(=O)c1cc(Sc2cnc(Nc3cccc(Br)n3)s2)ccc1C Show InChI InChI=1S/C20H22BrN5OS2/c1-13-7-8-14(11-15(13)19(27)26(3)10-9-22-2)28-18-12-23-20(29-18)25-17-6-4-5-16(21)24-17/h4-8,11-12,22H,9-10H2,1-3H3,(H,23,24,25) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of Met |
Bioorg Med Chem Lett 18: 634-9 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.076 BindingDB Entry DOI: 10.7270/Q2JD4WJ5 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50229101
(5-(2-(6-bromopyridin-2-ylamino)thiazol-5-ylthio)-N...)Show SMILES CNCCN(C)C(=O)c1cc(Sc2cnc(Nc3cccc(Br)n3)s2)ccc1C Show InChI InChI=1S/C20H22BrN5OS2/c1-13-7-8-14(11-15(13)19(27)26(3)10-9-22-2)28-18-12-23-20(29-18)25-17-6-4-5-16(21)24-17/h4-8,11-12,22H,9-10H2,1-3H3,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of CDK2 |
Bioorg Med Chem Lett 18: 634-9 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.076 BindingDB Entry DOI: 10.7270/Q2JD4WJ5 |
More data for this Ligand-Target Pair | |