BDBM50229102 1-(4-(2-methyl-5-(2-(pyridin-2-ylamino)thiazol-5-ylthio)benzyl)piperazin-1-yl)ethanone::CHEMBL427892

SMILES: CC(=O)N1CCN(Cc2cc(Sc3cnc(Nc4ccccn4)s3)ccc2C)CC1

InChI Key: InChIKey=MHUZXPHMBFANQR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50229102   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50229102 (1-(4-(2-methyl-5-(2-(pyridin-2-ylamino)thiazol-5-y...) Show SMILES CC(=O)N1CCN(Cc2cc(Sc3cnc(Nc4ccccn4)s3)ccc2C)CC1 Show InChI InChI=1S/C22H25N5OS2/c1-16-6-7-19(13-18(16)15-26-9-11-27(12-10-26)17(2)28)29-21-14-24-22(30-21)25-20-5-3-4-8-23-20/h3-8,13-14H,9-12,15H2,1-2H3,(H,23,24,25)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of TrkA				Bioorg Med Chem Lett 18: 634-9 (2008) Article DOI: 10.1016/j.bmcl.2007.11.076 BindingDB Entry DOI: 10.7270/Q2JD4WJ5
					More data for this Ligand-Target Pair