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BDBM50229108 1-(4-(4-(2-(6-bromopyridin-2-ylamino)thiazol-5-ylthio)benzoyl)piperazin-1-yl)ethanone::CHEMBL398474

SMILES: CC(=O)N1CCN(CC1)C(=O)c1ccc(Sc2cnc(Nc3cccc(Br)n3)s2)cc1

InChI Key: InChIKey=UZBWVIWDQYBJDL-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50229108   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50229108
PNG
(1-(4-(4-(2-(6-bromopyridin-2-ylamino)thiazol-5-ylt...)
Show SMILES CC(=O)N1CCN(CC1)C(=O)c1ccc(Sc2cnc(Nc3cccc(Br)n3)s2)cc1
Show InChI InChI=1S/C21H20BrN5O2S2/c1-14(28)26-9-11-27(12-10-26)20(29)15-5-7-16(8-6-15)30-19-13-23-21(31-19)25-18-4-2-3-17(22)24-18/h2-8,13H,9-12H2,1H3,(H,23,24,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of TrkA


Bioorg Med Chem Lett 18: 634-9 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.076
BindingDB Entry DOI: 10.7270/Q2JD4WJ5
More data for this
Ligand-Target Pair