BDBM50229111 (2-methyl-5-(2-(pyridin-2-ylamino)thiazol-5-ylthio)phenyl)(piperazin-1-yl)methanone::CHEMBL403344

SMILES: Cc1ccc(Sc2cnc(Nc3ccccn3)s2)cc1C(=O)N1CCNCC1

InChI Key: InChIKey=DQXCPRDAVDPEBG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50229111   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50229111 ((2-methyl-5-(2-(pyridin-2-ylamino)thiazol-5-ylthio...) Show SMILES Cc1ccc(Sc2cnc(Nc3ccccn3)s2)cc1C(=O)N1CCNCC1 Show InChI InChI=1S/C20H21N5OS2/c1-14-5-6-15(12-16(14)19(26)25-10-8-21-9-11-25)27-18-13-23-20(28-18)24-17-4-2-3-7-22-17/h2-7,12-13,21H,8-11H2,1H3,(H,22,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of TrkA				Bioorg Med Chem Lett 18: 634-9 (2008) Article DOI: 10.1016/j.bmcl.2007.11.076 BindingDB Entry DOI: 10.7270/Q2JD4WJ5
					More data for this Ligand-Target Pair