BDBM50229115 (5-(2-(6-bromopyridin-2-ylamino)thiazol-5-ylthio)-2-methylphenyl)(4-ethylpiperazin-1-yl)methanone::CHEMBL254893
SMILES: CCN1CCN(CC1)C(=O)c1cc(Sc2cnc(Nc3cccc(Br)n3)s2)ccc1C
InChI Key: InChIKey=JUFJPPYYAUZVAR-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50229115 ((5-(2-(6-bromopyridin-2-ylamino)thiazol-5-ylthio)-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of TrkA | Bioorg Med Chem Lett 18: 634-9 (2008) Article DOI: 10.1016/j.bmcl.2007.11.076 BindingDB Entry DOI: 10.7270/Q2JD4WJ5 | |||||||||||
More data for this Ligand-Target Pair |