BDBM50229199 CHEMBL398884::thiophene-2-carboxylic acid (4-hydroxy-biphenyl-3-yl)-amide

SMILES: Oc1ccc(cc1NC(=O)c1cccs1)-c1ccccc1

InChI Key: InChIKey=ZDKNSGWZSHUWOU-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50229199   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50229199 (CHEMBL398884 | thiophene-2-carboxylic acid (4-hydr...) Show SMILES Oc1ccc(cc1NC(=O)c1cccs1)-c1ccccc1 Show InChI InChI=1S/C17H13NO2S/c19-15-9-8-13(12-5-2-1-3-6-12)11-14(15)18-17(20)16-7-4-10-21-16/h1-11,19H,(H,18,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of HDAC1				Bioorg Med Chem Lett 18: 726-31 (2008) Article DOI: 10.1016/j.bmcl.2007.11.047 BindingDB Entry DOI: 10.7270/Q28W3D1M
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50229199 (CHEMBL398884 | thiophene-2-carboxylic acid (4-hydr...) Show SMILES Oc1ccc(cc1NC(=O)c1cccs1)-c1ccccc1 Show InChI InChI=1S/C17H13NO2S/c19-15-9-8-13(12-5-2-1-3-6-12)11-14(15)18-17(20)16-7-4-10-21-16/h1-11,19H,(H,18,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of HDAC1				Bioorg Med Chem Lett 18: 973-8 (2008) Article DOI: 10.1016/j.bmcl.2007.12.031 BindingDB Entry DOI: 10.7270/Q2765G5S
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50229199 (CHEMBL398884 | thiophene-2-carboxylic acid (4-hydr...) Show SMILES Oc1ccc(cc1NC(=O)c1cccs1)-c1ccccc1 Show InChI InChI=1S/C17H13NO2S/c19-15-9-8-13(12-5-2-1-3-6-12)11-14(15)18-17(20)16-7-4-10-21-16/h1-11,19H,(H,18,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of HDAC6				Bioorg Med Chem Lett 18: 726-31 (2008) Article DOI: 10.1016/j.bmcl.2007.11.047 BindingDB Entry DOI: 10.7270/Q28W3D1M
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM50229199 (CHEMBL398884 | thiophene-2-carboxylic acid (4-hydr...) Show SMILES Oc1ccc(cc1NC(=O)c1cccs1)-c1ccccc1 Show InChI InChI=1S/C17H13NO2S/c19-15-9-8-13(12-5-2-1-3-6-12)11-14(15)18-17(20)16-7-4-10-21-16/h1-11,19H,(H,18,20)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.81E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of HDAC3				Bioorg Med Chem Lett 18: 726-31 (2008) Article DOI: 10.1016/j.bmcl.2007.11.047 BindingDB Entry DOI: 10.7270/Q28W3D1M
					More data for this Ligand-Target Pair