BDBM50229648 (S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-3,5-dimethylphenyl)piperidin-1-ylsulfonyl)methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate::CHEMBL254295

SMILES: Cc1cc(cc(C)c1C#N)C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO

InChI Key: InChIKey=REAAGXUAXYMPTM-QFIPXVFZSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50229648   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Homo sapiens (Human))	BDBM50229648 ((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-3,5-dimeth...) Show SMILES Cc1cc(cc(C)c1C#N)C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO Show InChI InChI=1S/C26H36N4O7S/c1-18-13-21(14-19(2)23(18)15-27)20-3-8-30(9-4-20)38(34,35)17-26(24(31)28-33)6-10-29(11-7-26)25(32)37-22-5-12-36-16-22/h13-14,20,22,33H,3-12,16-17H2,1-2H3,(H,28,31)/t22-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	96	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition of HER2 sheddase in human BT474 cells				Bioorg Med Chem Lett 18: 560-4 (2008) Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50229648 ((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-3,5-dimeth...) Show SMILES Cc1cc(cc(C)c1C#N)C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO Show InChI InChI=1S/C26H36N4O7S/c1-18-13-21(14-19(2)23(18)15-27)20-3-8-30(9-4-20)38(34,35)17-26(24(31)28-33)6-10-29(11-7-26)25(32)37-22-5-12-36-16-22/h13-14,20,22,33H,3-12,16-17H2,1-2H3,(H,28,31)/t22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	535	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition of MMP9				Bioorg Med Chem Lett 18: 560-4 (2008) Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50229648 ((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-3,5-dimeth...) Show SMILES Cc1cc(cc(C)c1C#N)C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO Show InChI InChI=1S/C26H36N4O7S/c1-18-13-21(14-19(2)23(18)15-27)20-3-8-30(9-4-20)38(34,35)17-26(24(31)28-33)6-10-29(11-7-26)25(32)37-22-5-12-36-16-22/h13-14,20,22,33H,3-12,16-17H2,1-2H3,(H,28,31)/t22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition of MMP2				Bioorg Med Chem Lett 18: 560-4 (2008) Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50229648 ((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-3,5-dimeth...) Show SMILES Cc1cc(cc(C)c1C#N)C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO Show InChI InChI=1S/C26H36N4O7S/c1-18-13-21(14-19(2)23(18)15-27)20-3-8-30(9-4-20)38(34,35)17-26(24(31)28-33)6-10-29(11-7-26)25(32)37-22-5-12-36-16-22/h13-14,20,22,33H,3-12,16-17H2,1-2H3,(H,28,31)/t22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	756	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition of MMP3				Bioorg Med Chem Lett 18: 560-4 (2008) Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50229648 ((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-3,5-dimeth...) Show SMILES Cc1cc(cc(C)c1C#N)C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO Show InChI InChI=1S/C26H36N4O7S/c1-18-13-21(14-19(2)23(18)15-27)20-3-8-30(9-4-20)38(34,35)17-26(24(31)28-33)6-10-29(11-7-26)25(32)37-22-5-12-36-16-22/h13-14,20,22,33H,3-12,16-17H2,1-2H3,(H,28,31)/t22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition of MMP1				Bioorg Med Chem Lett 18: 560-4 (2008) Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Homo sapiens (Human))	BDBM50229648 ((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-3,5-dimeth...) Show SMILES Cc1cc(cc(C)c1C#N)C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO Show InChI InChI=1S/C26H36N4O7S/c1-18-13-21(14-19(2)23(18)15-27)20-3-8-30(9-4-20)38(34,35)17-26(24(31)28-33)6-10-29(11-7-26)25(32)37-22-5-12-36-16-22/h13-14,20,22,33H,3-12,16-17H2,1-2H3,(H,28,31)/t22-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition of ADAM10				Bioorg Med Chem Lett 18: 560-4 (2008) Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ
					More data for this Ligand-Target Pair