BDBM50231739 2-(4-phenyl-piperazin-1-yl)-7,8-dihydro-6H-quinolin-5-one::CHEMBL253145

SMILES: O=C1CCCc2nc(ccc12)N1CCN(CC1)c1ccccc1

InChI Key: InChIKey=NFCRALCGQNZQSY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50231739   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (RAT)	BDBM50231739 (2-(4-phenyl-piperazin-1-yl)-7,8-dihydro-6H-quinoli...) Show SMILES O=C1CCCc2nc(ccc12)N1CCN(CC1)c1ccccc1 Show InChI InChI=1S/C19H21N3O/c23-18-8-4-7-17-16(18)9-10-19(20-17)22-13-11-21(12-14-22)15-5-2-1-3-6-15/h1-3,5-6,9-10H,4,7-8,11-14H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Synthesis Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphate				J Med Chem 51: 634-47 (2008) Article DOI: 10.1021/jm0611298 BindingDB Entry DOI: 10.7270/Q2QC04B2
					More data for this Ligand-Target Pair