BDBM50231741 2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one::CHEMBL252956
SMILES: O=C1CCCc2nc(ccc12)C#Cc1ccccc1
InChI Key: InChIKey=XOUDFZJCSDKXLG-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Metabotropic glutamate receptor (Rattus norvegicus (Rat)) | BDBM50231741 (2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Synthesis Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from rat mGluR5 | J Med Chem 51: 634-47 (2008) Article DOI: 10.1021/jm0611298 BindingDB Entry DOI: 10.7270/Q2QC04B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor (Rattus norvegicus (Rat)) | BDBM50231741 (2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 34 | n/a | n/a | n/a | n/a |
Institute of Organic Synthesis Curated by ChEMBL | Assay Description Antagonist activity at mGluR5 in Sprague-Dawley rat astrocyte assessed as L-quisqualate induced potensiation of intracellular calcium level by FLIPR ... | J Med Chem 51: 634-47 (2008) Article DOI: 10.1021/jm0611298 BindingDB Entry DOI: 10.7270/Q2QC04B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50231741 (2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 172 | n/a | n/a | n/a | n/a |
Institute of Organic Synthesis Curated by ChEMBL | Assay Description Antagonist activity at human mGluR5 expressed in CHO cells assessed as L-glutamate induced potensiation of intracellular calcium level by FLIPR assay | J Med Chem 51: 634-47 (2008) Article DOI: 10.1021/jm0611298 BindingDB Entry DOI: 10.7270/Q2QC04B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50231741 (2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a |
Merz Pharmaceuticals GmbH Curated by ChEMBL | Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation... | Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50231741 (2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals Curated by ChEMBL | Assay Description Positive allosteric modulation of human mGlu4 receptor expressed in human HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliza... | Bioorg Med Chem Lett 21: 1402-6 (2011) Article DOI: 10.1016/j.bmcl.2011.01.027 BindingDB Entry DOI: 10.7270/Q2Q81DC5 | |||||||||||
More data for this Ligand-Target Pair |