BindingDB PrimarySearch

BDBM50231957 7-(3-Chloro-benzyloxy)-3,4-dimethyl-chromen-2-one::7-(3-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-one::CHEMBL109018

SMILES: Cc1c(C)c(=O)oc2cc(OCc3cccc(Cl)c3)ccc12

InChI Key: InChIKey=QYAGHNCHSVGMMO-UHFFFAOYSA-N

Data: 9 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50231957
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Acetylcholinesterase (Homo sapiens (Human))	BDBM50231957 (7-(3-Chloro-benzyloxy)-3,4-dimethyl-chromen-2-one ...) Show SMILES Cc1c(C)c(=O)oc2cc(OCc3cccc(Cl)c3)ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bologna Curated by ChEMBL					Assay Description Inhibition of human AchE				J Med Chem 51: 347-72 (2008) Article DOI: 10.1021/jm7009364 BindingDB Entry DOI: 10.7270/Q25B039W
University of Bologna Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM50231957 (7-(3-Chloro-benzyloxy)-3,4-dimethyl-chromen-2-one ...) Show SMILES Cc1c(C)c(=O)oc2cc(OCc3cccc(Cl)c3)ccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Bologna Curated by ChEMBL					Assay Description Inhibition of MAOB				J Med Chem 51: 347-72 (2008) Article DOI: 10.1021/jm7009364 BindingDB Entry DOI: 10.7270/Q25B039W
University of Bologna Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase (flavin-containing) A (Homo sapiens (Human))	BDBM50231957 (7-(3-Chloro-benzyloxy)-3,4-dimethyl-chromen-2-one ...) Show SMILES Cc1c(C)c(=O)oc2cc(OCc3cccc(Cl)c3)ccc12 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bologna Curated by ChEMBL					Assay Description Inhibition of MAOA				J Med Chem 51: 347-72 (2008) Article DOI: 10.1021/jm7009364 BindingDB Entry DOI: 10.7270/Q25B039W
University of Bologna Curated by ChEMBL					More data for this Ligand-Target Pair
Monoamine oxidase (Rattus norvegicus (rat))	BDBM50231957 (7-(3-Chloro-benzyloxy)-3,4-dimethyl-chromen-2-one ...) Show SMILES Cc1c(C)c(=O)oc2cc(OCc3cccc(Cl)c3)ccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lausanne Curated by ChEMBL					Assay Description Inhibitory activity against monoamine oxidase A				J Med Chem 44: 3195-8 (2001) BindingDB Entry DOI: 10.7270/Q2HQ417K
Universit£ de Lausanne Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM50231957 (7-(3-Chloro-benzyloxy)-3,4-dimethyl-chromen-2-one ...) Show SMILES Cc1c(C)c(=O)oc2cc(OCc3cccc(Cl)c3)ccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.14	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of human supersomes MAOB				J Med Chem 49: 6264-72 (2006) Article DOI: 10.1021/jm060441e BindingDB Entry DOI: 10.7270/Q2X63P5Q
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Monoamine Oxidase Type B (MAO-B) (Rattus norvegicus (rat))	BDBM50231957 (7-(3-Chloro-benzyloxy)-3,4-dimethyl-chromen-2-one ...) Show SMILES Cc1c(C)c(=O)oc2cc(OCc3cccc(Cl)c3)ccc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.31	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lausanne Curated by ChEMBL					Assay Description Inhibitory effect on Monoamine oxidase B, SD on IC50 values < 10%				J Med Chem 43: 4747-58 (2000) BindingDB Entry DOI: 10.7270/Q20K29RT
Universit£ de Lausanne Curated by ChEMBL					More data for this Ligand-Target Pair
Monoamine oxidase (Rattus norvegicus (rat))	BDBM50231957 (7-(3-Chloro-benzyloxy)-3,4-dimethyl-chromen-2-one ...) Show SMILES Cc1c(C)c(=O)oc2cc(OCc3cccc(Cl)c3)ccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lausanne Curated by ChEMBL					Assay Description Inhibitory effect on monoamine oxidase A, SD on IC50 values < 10%				J Med Chem 43: 4747-58 (2000) BindingDB Entry DOI: 10.7270/Q20K29RT
Universit£ de Lausanne Curated by ChEMBL					More data for this Ligand-Target Pair
Monoamine Oxidase Type B (MAO-B) (Rattus norvegicus (rat))	BDBM50231957 (7-(3-Chloro-benzyloxy)-3,4-dimethyl-chromen-2-one ...) Show SMILES Cc1c(C)c(=O)oc2cc(OCc3cccc(Cl)c3)ccc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.31	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of rat brain MAOB				J Med Chem 49: 6264-72 (2006) Article DOI: 10.1021/jm060441e BindingDB Entry DOI: 10.7270/Q2X63P5Q
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Monoamine Oxidase Type B (MAO-B) (Rattus norvegicus (rat))	BDBM50231957 (7-(3-Chloro-benzyloxy)-3,4-dimethyl-chromen-2-one ...) Show SMILES Cc1c(C)c(=O)oc2cc(OCc3cccc(Cl)c3)ccc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lausanne Curated by ChEMBL					Assay Description Inhibitory activity against monoamine oxidase B				J Med Chem 44: 3195-8 (2001) BindingDB Entry DOI: 10.7270/Q2HQ417K
Universit£ de Lausanne Curated by ChEMBL					More data for this Ligand-Target Pair